E. For the two mechanisms of apoptosis that do require cytochrome c release, which requires caspase activity for this release to occur? How does this caspase activity promote cytochrome c release?

Human Anatomy & Physiology (11th Edition)
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Author:Elaine N. Marieb, Katja N. Hoehn
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Chapter1: The Human Body: An Orientation
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E. For the two mechanisms of apoptosis that do require cytochrome c release, which
requires caspase activity for this release to occur? How does this caspase activity promote
cytochrome c release?
F. In figure C, ZVAD is an inhibitor of all caspases in the cell. What is the effect of ZVAD
addition with protein X overexpression on release of cytochrome c as compared to
overexpression of protein X alone?
9 cepamane o
G. Using the results from figure C, what is the most likely mechanism (loss of growth
signals, extrinsic, or intrinsic) that protein X utilizes to promote apoptosis? How do the
results from figure C, help you narrow down your choice from part D?
H. Using your knowledge of apoptotic signaling proteins, propose an identity of protein X
given the information included in the figures. Explain how that protein promotes
apoptosis.
Transcribed Image Text:E. For the two mechanisms of apoptosis that do require cytochrome c release, which requires caspase activity for this release to occur? How does this caspase activity promote cytochrome c release? F. In figure C, ZVAD is an inhibitor of all caspases in the cell. What is the effect of ZVAD addition with protein X overexpression on release of cytochrome c as compared to overexpression of protein X alone? 9 cepamane o G. Using the results from figure C, what is the most likely mechanism (loss of growth signals, extrinsic, or intrinsic) that protein X utilizes to promote apoptosis? How do the results from figure C, help you narrow down your choice from part D? H. Using your knowledge of apoptotic signaling proteins, propose an identity of protein X given the information included in the figures. Explain how that protein promotes apoptosis.
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