Drug XYZ has the following dosing guidelines: initiate therapy at 4-6mg/kg/day IV once daily for 2 days, then decrease dosage by 25% for days 3 and 4, then discontinue. The prescriber has ordered an initial dose of 5mg/kg/day IV for a 48 YO 176lb male. The drug is available in 10mL vials and labeled 100mg/mL. a) How many mL will you administer on day 1? b) How many mL will you administer on day 3?
Drug XYZ has the following dosing guidelines:
initiate therapy at 4-6mg/kg/day IV once daily for 2 days, then decrease dosage by 25% for days 3 and 4, then discontinue. The prescriber has ordered an initial dose of 5mg/kg/day IV for a 48 YO 176lb male. The drug is available in 10mL vials and labeled 100mg/mL.
a) How many mL will you administer on day 1?
b) How many mL will you administer on day 3?
- Patient's weight: 176 lb
- Initial dose: 5 mg/kg/day
Step 1: Convert the patient's weight from pounds (lb) to kilograms (kg): Patient's weight = 176 lb ÷ 2.205 lb/kg ≈ 79.7 kg (rounded to the nearest tenth)
Step 2: Calculate the total dose for Day 1: Total dose for Day 1 = Patient's weight (kg) × Initial dose (mg/kg/day) Total dose for Day 1 = 79.7 kg × 5 mg/kg/day = 398.5 mg
Step 3: Calculate the volume (mL) needed for Day 1: Volume for Day 1 = Total dose (mg) / Concentration (mg/mL) Volume for Day 1 = 398.5 mg / 100 mg/mL = 3.985 mL
You will administer approximately 3.99 mL on Day 1 (rounded to the nearest hundredth).
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