A patient's medication history lists they are taking Drug C. The drug manual states that C Drug C relies heavily on CYP-450 for
A) Increase the dose of Drug C if ketoconazole is ordered.
B ) Make them aware of potential toxicity if efavirenz is ordered.
C) Make them aware of potential subtherapeutic drug levels if erythromycin is ordered.
D ) Reduce the dose of Drug C if phenytoin is ordered
The nurse should contact the prescriber to:
C) Make them aware of potential subtherapeutic drug levels if erythromycin is ordered.
Explanation: Erythromycin is known to inhibit CYP-450 enzymes, which are essential for the metabolism of Drug C. If erythromycin is ordered along with Drug C, it could significantly slow down the metabolism of Drug C, leading to reduced drug levels in the patient's bloodstream. This can result in subtherapeutic drug levels, meaning that the drug may not be effective at the intended dose. Therefore, it is crucial for the nurse to inform the prescriber about this potential interaction so that appropriate adjustments to the dosage of Drug C can be made to ensure its therapeutic efficacy.
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