Answered: Drug A has a log P of -1.88 and Drug B…

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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Drug A has a log P of -1.88 and Drug B has a log P of -1.09. Which drug would more easily dissolve in the GI tract and why? Answers A-D A Drug A because it is more lipophilic than Drug B B Drug B because it is more hydrophilic than Drug A C Drug A because it is more hydrophilic than Drug B 5 D Drug B because it is more lipophilic than Drug A

Expert Solution

Step 1

Partition coefficient: It is defined as the ratio of the unionized drug distributed between the organic phase and the aqueous phase.

There are a few important points :

log P value will reflect that the compound has an affinity for the lipid phase and the compound is lipophilic
Negative value of log p means the compounds have the ability of aqueous phase.
The gastrointestinal tract is a continuous tube extending from mouth to anus. The gastrointestinal tract includes the oral cavity, pharynx, esophagus, stomach, small intestine, and large intestine.

The mucosa, which lines the lumen of the gastrointestinal tract, is absorptive. The GI tract is acidic so it is ionic in nature.
The drug molecules diffuse from regions of higher concentration to regions of lower concentration till the equilibrium is attained.
Greater the surface area, the lesser the thickness of the membrane, and the faster the diffusion.

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