An amount of 20 uCi of 32p (TR 14.3 d) is injected into the bloodstream of a reference adult ( m =70 kg). 32p is metabolized in such a way that 40% is uniformly distributed throughout the whole body where it is cleared with a biological half-life of 19 d. What is the effective half-life of 32p in the total body?
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- Determine the Ki for the inhibitor at 30 °Cand decide what type of inhibitor is being used. Eo T I S V (g/I) (°C) (mmol/ml) (mmol/ml) (mmol/ml-min) 1.6 30 0.1 2.63 1.6 30 0.033 1.92 1.6 30 0.02 1.47 1.6 30 0.01 0.96 1.6 30 0.005 0.56 1.6 49.6 0.1 5.13 1.6 49.6 0.033 3.70 1.6 49.6 0.01 1.89 1.6 49.6 0.0067 1.43 1.6 49.6 0.005 1.11 0.92 30 0.1 1.64 0.92 30 0.02 0.90 0.92 30 0.01 0.58 0.92 30 0.6 0.1 1.33 0.92 30 0.6 0.033 0.80 0.92 30 0.6 0.02 0.57Cimetidine is used in the treatment and management of gastric ulcers and gastroesophageal reflux disease. In the case of an active ulcer, cimetidine can be administered continuous by IV infusion at a dose rate of 37.5 mg/hr. If the concentration of the cimetidine solution is 6 mg/ml, then how many milliliters must be available for a 4-hr infusion?Misoprostol is used to prevent NSAID-induced gastric ulcers. A daily dose consists of two tablets administered four times each day. What is the size of one day’s dose if each tablet contains 100 mcg of misoprostol?rug-B has an elimination half-life of 9 hours, an absorption half-life of 20 minutes and linear harmacokinetics. In a patient, the plasma concentration five hours from the administration of two 60 mg cablets of the drug is 8 ug/mL. What would you expect to be the plasma concentration five hours from the administration of one 60 mg tablets? 1 ug/mL Answer 1-1
- The N excess/deficit factor for 100 kg of an organic material that contained 60% C (carbon) and 0.5% N (nitrogen) would likely be (assuming that 35% of the carbon is metabolized by microorganisms and the carbon and nitrogen are assimilated in a 10:1 ratio). -3.85 kg (deficit, N immobilization) -1.05 kg (deficit, N immobilization) -2.50 kg (deficit, N immobilization) -1.60 kg (deficit, N immobilization) -2.15 kg (deficit, N immobilization)Aerobic degradation of an organic compound by mixed cultureof organism in wastewater can be represented by following reaction. C3H6O3 + a O2 + b NH3 → c C5H7NO2 + d H2o + e CO2 A. Determine a, b, c, d and e, if YX/S = 0.4 d X/g S. B. Determine the yield coefficients YX/O2 and YX/NH3. C. Determine the degree of reductions for the substrate, bacteria and RQ for the organismsTo determine the metabolizable energy (ME) of a petfood, I can use Modified Atwater Values (3.5, 3.5 and 8.5 Kcal/kg for NFE, protein and fat, respectively). Below is my petfood label. Calcluate the ME for the label in Kcal/kg. Moisture = 10% Protein = 28% Fat = 14% Ash = 4% Fiber = 4%
- Paclitaxel is used to treat ovarian cancer by infusion at a concentration of 0.6 mg/mL over 24 hours. A dose of 135 mg/m² has been prescribed for Sero. Sero is 1.06 m tall and weighs 92 kg. Paclitaxel comes in vials of 150 mg/25 mL. Calculate the volume of 5%w/v glucose solution that would be required to dilute the concentrated solution to prepare an paclitaxel solution of the required strength.Paclitaxel is used to treat ovarian cancer by infusion at a concentration of 0.6 mg/mL over 24 hours. A dose of 135 mg/m² has been prescribed for Sero. Sero is 1.06 m tall and weighs 92 kg. Paclitaxel comes in vials of 150 mg/25 mL. Calculate the volume of 5%w/v glucose solution that would be required to dilute the concentrated solution to prepare an paclitaxel solution of the required strength. Answer: You did not give the correct unit. The correct answer is: 333 mL XO Ara (Alt+ Ğ) Yeni. - Gözden Geçir Görünüm Yardım Başvurular Posta Gönderileri 1) Discuss this graph in the meaning of substrate depletion. 100 80 [S] [P] 60 40 20 20 40 60 80 100 Time (s.) ere goz atın 7SUS 17 19 5 8. 9. Relative Concentration
- Indinavir has a pka of 5.0, and 10 (A) what is the % dissociation in stomach (pH =8) 50 75 100Based on this graph, it appears that carboxylesterase is most active at a pH of A. 3.5B. 1.5C. 5D. 4The hydrolysis of a substrate, S, by an enzyme has been studied in the lab. The following initial rates, vo, were recorded at different concentrations. [S] (M) Vo (M/min) 2.10-10-4 1.20.10-6 4.20-10-4 3.10.10-6 9.30-10-4 6.30-10-6 1.42-10-3 9.10-10-6 A. Determine the rate constants for degradation of the substrate B. What is the rate of reaction at [S] = 1.1.104 M? C. Explain, why enzymes can make reactions go faster? Does enzymes also catalyse the reverse reaction from product to substrate?