Determine a molecular cause that allows explaining the BIOCHEMICAL alterations found in the following patient; Determine their estimated 10-year cardiovascular risk. A 37-year-old patient, a woman who has smoked for 10 years, consulted for malaise, headache, nausea, and fatigue. The medical examination found tendon xanthomas, skin xanthomas, signs of atherosclerosis. Laboratory test Glycemia 90 mg/dL, total cholesterol 560 mg//dL, TAG 230 mg/dL, cHDL 33 mg/dl.
Determine a molecular cause that allows explaining the BIOCHEMICAL alterations found in the following patient; Determine their estimated 10-year cardiovascular risk. A 37-year-old patient, a woman who has smoked for 10 years, consulted for malaise, headache, nausea, and fatigue. The medical examination found tendon xanthomas, skin xanthomas, signs of atherosclerosis. Laboratory test Glycemia 90 mg/dL, total cholesterol 560 mg//dL, TAG 230 mg/dL, cHDL 33 mg/dl.
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Determine a molecular cause that allows explaining the BIOCHEMICAL alterations found in the following patient; Determine their estimated 10-year cardiovascular risk. A 37-year-old patient, a woman who has smoked for 10 years, consulted for malaise, headache, nausea, and fatigue. The medical examination found tendon xanthomas, skin xanthomas, signs of atherosclerosis. Laboratory test Glycemia 90 mg/dL, total cholesterol 560 mg//dL, TAG 230 mg/dL, cHDL 33 mg/dl.
Transcribed Image Text:Table III.1-6. 10-Year Risk Estimates for Women (Framingham Point Scores)
Age
20-34
35-39
40-44
45-49
50-54
HDL
Points
-7
-3
0
3
55-59
60-64
65-60 12
70-74
14
75-79 16
50-50
40-49
<40
6
B
10
Points
1
0
1
2
Total
Cholesterol
<160
160-199
200-239
240-279
>280
Normoker
Smoker
Systolic BP
<120
120.129
130-130
140-150
2160
Point Total
<9
9
10
11
12
13
14
15
16
17
18
19
Points at
Ages 20-39
0
8
11
13
Points at
Ages 20-39
oa
0
9
2%
2%
3%
5%
Points at
Ages 40-49
10-Year Rink
<1%
1%
1%
1%
1%
8%
3
6
10
Points at
Ages 40.49
0
7
#Untreated
3
Points at
Ages 50-59
0
2
4
5
7
Points at
Ages 50.59
0
4
Point Total
20
21
22
23
24
225
Points at
Ages 60-69
0
1
2
3
4
Points at
Ages 60.69
NO
2
If Treated
0
3
4
5
6
Points at
Ages 70-79
0
1
1
>30%
2
2
Points at
Ages 70-79
0
1
10-Year Risk
11%
14%
17%
22%
27%
Transcribed Image Text:Table III.1-5. Estimate of 10-Year Risk for Men (Framingham Point Scores)
Age
20-34
40.44
50-54
55-59
60-64
65.60
70-76
75-79
HDL
260
50-50
40-49
<40
Points
-9
4
0
3
6
8
10
11
12
13
Points
-1
0
1
2
Total
Cholesterol
<160
160-199
200-230
240-279
2280
Nonsmoker
Smoker
Systolic BP
<120
120-129
130-139
140-159
2160
Point Total
0
1
2
3
4
5
7
8
10
Points at
Ages 20.39
0
4
7
9
11
Points at
Ages 20-39
0
B
***********
1%
10-Year Risk
<1%
1%
1%
1%
1%
2%
2%
3%
4%
5%
Points at
Agen 40.49
0
3
6%
5
6
8
Points at
Ages 40-49
0
5
If Untreated
0
0
1
1
2
Points at
Agen 50.59
0
2
3
4
5
Points at
Ages 50-59
0
3
Point Total
11
12
13
14
15
16
217
Points at
Agen GO.CO
0
1
1
2
3
Points at
Ages 60-69
1
#Treated
0
1
2
2
3
Points at
Agen 70-79
0
0
0
1
1
Points at
Ages 70-79
0
1
10-Year Risk
8%
10%
12%
16%.
20%
25%
>30%
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