Describe the experiment done by Frederick Griffith in 1928, where the non-lethal (rough) strain of Streptococcus pneumoniae bacteria killed experimental mice when mixed with the heat-killed smooth strain. Discuss what may have happened to the rough strain after the heat-killed smooth strain was introduced and why you think the rough strain killed the mice. What
Describe the experiment done by Frederick Griffith in 1928, where the non-lethal (rough) strain of Streptococcus pneumoniae bacteria killed experimental mice when mixed with the heat-killed smooth strain. Discuss what may have happened to the rough strain after the heat-killed smooth strain was introduced and why you think the rough strain killed the mice. What
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
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Describe the experiment done by Frederick Griffith in 1928, where the non-lethal (rough) strain of Streptococcus pneumoniae bacteria killed experimental mice when mixed with the heat-killed smooth strain. Discuss what may have happened to the rough strain after the heat-killed smooth strain was introduced and why you think the rough strain killed the mice. What would be the conclusion and significance of this study and its finding?
Expert Solution

Step 1
Frederick Griffith was a British bacteriologist.He was a physician, pathologist and a bacteriologist.Frederick Griffith was born in Prescot,Merseyside , England.He presented Griffith experiment in January 1928.
Step 2
Griffith experiment was the first experiment which suggested that bacteria are able to transfer genetic material through a process called transformation.
Griffith used two strains of pneumococcus bacteria:
- Smooth strain:Virulent and produced a polysaccharide capsule for protection of itself from immune system of host
- Rough strain-non virulent and did not have any protective capsule and hence no protection from immune system of host
So steps in the experiment of Griffith are:
- S strain bacteria injected into mice and mice died
- R strain injected into mice and no death of mice
- When Griffith injected heat killed S into mice ,no death occurred
- When mixture of heat killed S and live R was injected,death occurred
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