Describe “mechanistically” how a folate and vitamin B12 deficiency might impact DNA transcription.
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Describe “mechanistically” how a folate and vitamin B12 deficiency might impact DNA transcription.
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- 10. Protein expression can be blocked by antisense oligonucleotides. Which mechanism enables antisense oligonucleotides to block protein synthesis? O Antisense oligonucleotides bind to ribosomes and inhibit their function. Antisense oligonucleotides bind to DNA in the nucleus and inhibit the synthesis o MRNA. Antisense oligonucleotides bind to ribosomal RNA (rRNA) and inhibit ribosome assembly. Antisense oligonucleotides bind to messenger RNA (MRNA) and prevents mRNA binding to ribosomes.1. Determine the effect of the following mutations on the DNA sequence. In each case, the mutation is described after the sequence (REFER TO THE SUPPLEMENTAL DOCUMENT FOR GUIDANCE TO THIS QUESTION). Adenine nucleotide (A shown in red below) was inserted into the DNA sequence at the position indicated by the arrow). Write out the sequence of the mutated DNA and the protein made from it. What is the effect of this mutation on the protein? (For example, how will the mutation affect the length and sequence of the protein? What about the function of the protein?) A 3' TACATGG'TTGTGCTAATT 5'C. Two mutations are known in the population, one shaded in yellow and one in blue, shown on the TEMPLATE DNA sequence below. Ursula has a mutation in the yellow- shaded underlined nucleotide: instead of an A in this position, she has a T. 5' AATCATAACTCATTG 3' What type of mutation does Ursula have? Second position First position (5 000 0 UUU UUC phe UUA UUG COU leu CỰU CUC CUA COO CUG ADO AUU AUC ile nov AUA AUG met GUU GUC GUA GUG val UCU UCC UCA ser UCA UCG COU CCU cce CCC CCA pro CCA CCG ACU www ACC ACA ACG GCU GCC GCA GCG thr ala UAU tyr UAC UAA Stop UAG Stop CAU CAC his CAC CAA gin CAG AAU AAC asn AAC AAA lys AAG GAU GAC asp glu GAA GAG UGU UGC cys UGA Stop UGG trp CGU Missense Silent Nonsense Frameshift CGC CGA arg CGA CGG AGU AGC AGA AGG GGU GGC GGA GGG Initiation Termination ser arg gly DUAG DUMU DUAU DUAG Third position (3-end)
- Pls briefly describe point mutation.Hi, can you please explain the clinical significance of G protein mutations.Path: p QUESTION 44 What precautions might you take when working in a BSL-2 lab? Is there a risk? T TTArial 3 (12pt) Path: p QUESTION 45 What are insertion and deletion mutations? Why might they be harmful to a cell? Click Save and Submit to save and submit. Click Save All Answers to save all answers. P Type here to search 立