(d) The antibacterial activity of a number of penicillins was found to fit the following QSAR equation (Figure Q13(d)): OX OX H H S CO2H Log(1/c) = -0.245 +1.720σ +5.673 (n=8, r=0.929) Figure Q13(d) What type of groups attached to the benzene ring give the highest antibacterial activity. Suggest at least two examples of substituent groups, which have the right properties to show antibacterial activity. (7 marks)

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(d)
The antibacterial activity of a number of penicillins was found to fit the
following QSAR equation (Figure Q13(d)):
OX
OX
H
H
S
CO2H
Log(1/c) = -0.245 +1.720σ +5.673 (n=8, r=0.929)
Figure Q13(d)
What type of groups attached to the benzene ring give the highest
antibacterial activity. Suggest at least two examples of substituent
groups, which have the right properties to show antibacterial activity.
(7 marks)
Transcribed Image Text:(d) The antibacterial activity of a number of penicillins was found to fit the following QSAR equation (Figure Q13(d)): OX OX H H S CO2H Log(1/c) = -0.245 +1.720σ +5.673 (n=8, r=0.929) Figure Q13(d) What type of groups attached to the benzene ring give the highest antibacterial activity. Suggest at least two examples of substituent groups, which have the right properties to show antibacterial activity. (7 marks)
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