3. Bioconjugate chemistry is a relatively new branch of science wherebybiological macromolecules, sometimes even from different classes, areconnected by a covalent bond or linkage. For example, a lipoprotein ora glycolipid in which part of the molecule is a lipid and part protein oris part carbohydrate and part protein can be considered a bioconjugate,and there are many other examples. After a bioconjugation synthesis,typically medicinal chemists use TLC to determine the extent of theirreaction where it can be used to separate the starting reactants from theproduct (the bioconjugate). For example, consider the reaction of twocysteine amino acids together in the formation of a disulfide bond andthe biological compound cystine (Eq. 3-2):Cys-SH + Cys-SHCys-S-S-Cys (Cystine)Eq. 3-2Draw or sketch what the TLC pattern might look like where thestarting material is separated by the disulfide-bond-linkeddipeptide.

TLC is a versatile and widely used technique in chemistry and biochemistry for separating and…

Answered: cysteine amino acids together in the…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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cysteine amino acids together in the formation of a disulfide bond and the biological compound cystine (Eq. 3-2): Cys-SH + Cys-SH Cys-S-S-Cys (Cystine) Eq. 3-2 Draw or sketch what the TLC pattern might look like where the starting material is separated by the disulfide-bond-linked dipeptide.