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Curare is a paralytic toxin once used by indigenous South American tribes to hunt game. The toxin works by blocking nicotinic receptors at the neuromuscular junction, causing paralysis and eventually death by asphyxiation (when the diaphragm becomes paralysed). If we pretend for a moment that the year is 1596 and you are the first 'outsider' to discover curare (hopefully not the hard way), and don't know its true mechanism, what other mechanisms could allow curare to have these paralytic effects? Choose all mechanisms which could lead to skeletal muscle paralysis (an inability to initiate a muscle contraction): O Inhibiting acetylcholinesterase at the neuromuscular junction. O Blocking voltage-gated Ca2+ channels in alpha-motor neurons. O Blocking reuptake of acetylcholine at the neuromuscular junction. O Causing the spontaneous release of acetylcholine at the neuromuscular junction. O Blocking voltage-gated Na+ channels in alpha-motor neurons.

Curare is a paralytic toxin once used by indigenous South American tribes to hunt game. The toxin works by blocking nicotinic receptors at the neuromuscular junction, causing paralysis and eventually death by asphyxiation (when the diaphragm becomes paralysed). If we pretend for a moment that the year is 1596 and you are the first 'outsider' to discover curare (hopefully not the hard way), and don't know its true mechanism, what other mechanisms could allow curare to have these paralytic effects? Choose all mechanisms which could lead to skeletal muscle paralysis (an inability to initiate a muscle contraction): O Inhibiting acetylcholinesterase at the neuromuscular junction. O Blocking voltage-gated Ca2+ channels in alpha-motor neurons. O Blocking reuptake of acetylcholine at the neuromuscular junction. O Causing the spontaneous release of acetylcholine at the neuromuscular junction. O Blocking voltage-gated Na+ channels in alpha-motor neurons.

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Curare is a paralytic toxin once used by indigenous South American tribes to hunt game. The toxin works by blocking nicotinic receptors at the neuromuscular junction, causing paralysis and eventually death by asphyxiation (when the diaphragm becomes paralysed). If we pretend for a moment that the year is 1596 and you are the first 'outsider' to discover curare (hopefully not the hard way), and don't know its true mechanism, what other mechanisms could allow curare to have these paralytic effects? Choose all mechanisms which could lead to skeletal muscle paralysis (an inability to initiate a muscle contraction): O Inhibiting acetylcholinesterase at the neuromuscular junction. Blocking voltage-gated Ca2+ channels in alpha-motor neurons. Blocking reuptake of acetylcholine at the neuromuscular junction. Causing the spontaneous release of acetylcholine at the neuromuscular junction. Blocking voltage-gated Na+ channels in alpha-motor neurons.
Transcribed Image Text:Curare is a paralytic toxin once used by indigenous South American tribes to hunt game. The toxin works by blocking nicotinic receptors at the neuromuscular junction, causing paralysis and eventually death by asphyxiation (when the diaphragm becomes paralysed). If we pretend for a moment that the year is 1596 and you are the first 'outsider' to discover curare (hopefully not the hard way), and don't know its true mechanism, what other mechanisms could allow curare to have these paralytic effects? Choose all mechanisms which could lead to skeletal muscle paralysis (an inability to initiate a muscle contraction): O Inhibiting acetylcholinesterase at the neuromuscular junction. Blocking voltage-gated Ca2+ channels in alpha-motor neurons. Blocking reuptake of acetylcholine at the neuromuscular junction. Causing the spontaneous release of acetylcholine at the neuromuscular junction. Blocking voltage-gated Na+ channels in alpha-motor neurons.
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