Could you please confirm which stage question number 4 would be? (Substitution, insertion,

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Could you please confirm which stage question number 4 would be? (Substitution, insertion, deletion).
Student Worksheet (V2)
carliest SARS-CoV-2 infections in the United States were detected in the state of Washington in January
2020. Scientists have since sequenced SARS-CoV-2 genomes from infected individuals throughout the country.
Table 1 shows some sequence data for the gene that encodes the spike protein, which was sequenced from
SARS-CoV-2 viruses collected in different states. (The last column of the table is left blank for you to fill in later.)
The gene's sequence in the virus collected from Washington early in the pandemic is between 99% and 100%
identical to that of viruses collected from Utah, Colorado, Kansas, and California later on. However, some
mutations have occurred at specific locations in the gene over time.
Table 1. Data on the sequences of spike proteins from SARS-CoV-2 viruses collected in different states from January to May
2020. Note that during the process of amplifying and sequencing the viral RNA genomes, the RNA is converted to DNA. Data
from GenBank,
Position in the sequence alignment
Number of
differences
State
1059
3037
14408
18060
23403
25563
28144
Washington
C
А
G
C
Utah
T
G
Colorado
C
C
A
G
$2
Kansas
C
G
G
California
T
G
3. Which of the following types of mutations is represented in Table 1?
substitutions
b. insertions
С.
deletions
4.
At which stage of viral infection did these mutations most likely occur?
/5. Fill in the last column of Table 1 to indicate the number of nucleotide differences between the virus from
Washington and the viruses from other states.
6. Knowing that the virus from Washington probably arose first, make a list below predicting the order, from
first to last, in which the viruses from these states arose.
a. Washington
b.
с.
d.
е.
www.Biolnteractive.org
Published August 2020
Page 4 of 5
Transcribed Image Text:Student Worksheet (V2) carliest SARS-CoV-2 infections in the United States were detected in the state of Washington in January 2020. Scientists have since sequenced SARS-CoV-2 genomes from infected individuals throughout the country. Table 1 shows some sequence data for the gene that encodes the spike protein, which was sequenced from SARS-CoV-2 viruses collected in different states. (The last column of the table is left blank for you to fill in later.) The gene's sequence in the virus collected from Washington early in the pandemic is between 99% and 100% identical to that of viruses collected from Utah, Colorado, Kansas, and California later on. However, some mutations have occurred at specific locations in the gene over time. Table 1. Data on the sequences of spike proteins from SARS-CoV-2 viruses collected in different states from January to May 2020. Note that during the process of amplifying and sequencing the viral RNA genomes, the RNA is converted to DNA. Data from GenBank, Position in the sequence alignment Number of differences State 1059 3037 14408 18060 23403 25563 28144 Washington C А G C Utah T G Colorado C C A G $2 Kansas C G G California T G 3. Which of the following types of mutations is represented in Table 1? substitutions b. insertions С. deletions 4. At which stage of viral infection did these mutations most likely occur? /5. Fill in the last column of Table 1 to indicate the number of nucleotide differences between the virus from Washington and the viruses from other states. 6. Knowing that the virus from Washington probably arose first, make a list below predicting the order, from first to last, in which the viruses from these states arose. a. Washington b. с. d. е. www.Biolnteractive.org Published August 2020 Page 4 of 5
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