Consider the following phenotype for hemophilia, a recessive X-linked blood clotting disorder, in decendents of Queen Victoria. Victoria is thought to have been a carrier for the recessive hemophilia allele. What is the probability that Princess Irene is also a carrier? Albert Victoria (1819-1901) Empress Victoria Alice of Hesse Edward Helena Leopold Beatrice VII Princess OOO Duke of Christian Albany Kaiser George Princess Frederick (Alexandra) Irene Victoria Leopold Maurice Eugenie (wife of Alfonso XII) Alice Wilhelm II V Alix Tsarina of Athlone Nikolas II

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The image presents a pedigree chart illustrating the inheritance pattern of hemophilia, an X-linked recessive blood clotting disorder. The chart traces the descendants of Queen Victoria, who is assumed to have been a carrier of the recessive hemophilia allele.

In the pedigree:

- Circles represent females and squares represent males.
- Shaded squares indicate males affected by hemophilia.
- Unshaded symbols indicate individuals who are unaffected or their carrier status is unknown.
- Individuals in the same generation are aligned horizontally.

The pedigree shows Queen Victoria and her consort Albert at the top. Below them are their offspring, which include Edward VII, Alice of Hesse, Helena Princess Christian, Leopold Duke of Albany, and Beatrice, among others.

Key details:
- Frederick, a son of Alice of Hesse, and Leopold, Duke of Albany, are shown to be affected by hemophilia, denoted by shaded blue squares.
- Maurice, a son of Beatrice, is also affected.

The question asks about the probability that Princess Irene, daughter of Alice of Hesse, is a carrier of the hemophilia allele. Given that hemophilia is an X-linked recessive disorder, understanding the inheritance patterns from Queen Victoria through her daughter Alice to her granddaughter Irene is crucial in estimating this probability.
Transcribed Image Text:The image presents a pedigree chart illustrating the inheritance pattern of hemophilia, an X-linked recessive blood clotting disorder. The chart traces the descendants of Queen Victoria, who is assumed to have been a carrier of the recessive hemophilia allele. In the pedigree: - Circles represent females and squares represent males. - Shaded squares indicate males affected by hemophilia. - Unshaded symbols indicate individuals who are unaffected or their carrier status is unknown. - Individuals in the same generation are aligned horizontally. The pedigree shows Queen Victoria and her consort Albert at the top. Below them are their offspring, which include Edward VII, Alice of Hesse, Helena Princess Christian, Leopold Duke of Albany, and Beatrice, among others. Key details: - Frederick, a son of Alice of Hesse, and Leopold, Duke of Albany, are shown to be affected by hemophilia, denoted by shaded blue squares. - Maurice, a son of Beatrice, is also affected. The question asks about the probability that Princess Irene, daughter of Alice of Hesse, is a carrier of the hemophilia allele. Given that hemophilia is an X-linked recessive disorder, understanding the inheritance patterns from Queen Victoria through her daughter Alice to her granddaughter Irene is crucial in estimating this probability.
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