consider diffusion of a drug across a two-layer membrane mounted in between two compartments (donor and receiver) of a diffusion cell. layer 1 in contact with the donor side is 0.1 mm thick and layer 2 in contact with the receiver size is 0.3 mm thick. the diffusion coefficient of the drug in layer 1 is 0.2 × 10−10 m2/s and in layer 2 is 0.1 × 10−10 m2/s. the partition coefficient of the drug in layer1 and layer 2 are 10 and 50, both with respect of concentration in water. the concentration in the donor and receiver chambers are fixed at 5 mg/ml and zero, respectively. calculate the flux of drug from the donor to the receiver chamber
consider diffusion of a drug across a two-layer membrane mounted in between two compartments (donor and receiver) of a diffusion cell. layer 1 in contact with the donor side is 0.1 mm thick and layer 2 in contact with the receiver size is 0.3 mm thick. the diffusion coefficient of the drug in layer 1 is 0.2 × 10−10 m2/s and in layer 2 is 0.1 × 10−10 m2/s. the partition coefficient of the drug in layer1 and layer 2 are 10 and 50, both with respect of concentration in water. the concentration in the donor and receiver chambers are fixed at 5 mg/ml and zero, respectively. calculate the flux of drug from the donor to the receiver chamber
Introduction to Chemical Engineering Thermodynamics
8th Edition
ISBN:9781259696527
Author:J.M. Smith Termodinamica en ingenieria quimica, Hendrick C Van Ness, Michael Abbott, Mark Swihart
Publisher:J.M. Smith Termodinamica en ingenieria quimica, Hendrick C Van Ness, Michael Abbott, Mark Swihart
Chapter1: Introduction
Section: Chapter Questions
Problem 1.1P
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consider diffusion of a drug across a two-layer membrane mounted in between two
compartments (donor and receiver) of a diffusion cell. layer 1 in contact with the donor side is 0.1 mm
thick and layer 2 in contact with the receiver size is 0.3 mm thick. the diffusion coefficient of the drug
in layer 1 is 0.2 × 10−10 m2/s and in layer 2 is 0.1 × 10−10 m2/s. the partition coefficient of the drug in
layer1 and layer 2 are 10 and 50, both with respect of concentration in water. the concentration in the
donor and receiver chambers are fixed at 5 mg/ml and zero, respectively. calculate the flux of drug
from the donor to the receiver chamber
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