Consider an acetyl CoA that enters the TCA cycle.  Let’s call this cycle “Cycle 1.”    Let’s say you put a radiolabel on the carbonyl carbon of acetyl CoA that will allow us to track this carbon through the TCA cycle.  Now, trace its path through the TCA cycle and answer the following questions:   (a) Does the carbonyl carbon of Acetyl CoA come out as CO2 in Cycle 1?    (b) If your answer to (a) was No, in which cycle does it come out as CO2 (Cycle 2, 3, 4 …)

Biochemistry
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ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
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Chapter1: Biochemistry: An Evolving Science
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Consider an acetyl CoA that enters the TCA cycle.  Let’s call this cycle “Cycle 1.” 

 

Let’s say you put a radiolabel on the carbonyl carbon of acetyl CoA that will allow us to track this carbon through the TCA cycle.  Now, trace its path through the TCA cycle and answer the following questions:

 

(a) Does the carbonyl carbon of Acetyl CoA come out as CO2 in Cycle 1? 

 

(b) If your answer to (a) was No, in which cycle does it come out as CO2 (Cycle 2, 3, 4 …)

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