Why is a high mean corpuscular hemoglobinconcentration (MCHC) in a patientcorrelated with hereditary spherocytosisA 48-year-old woman with a 3-day history ofnausea and vomiting has deep sighingrespiration and her breath smells sweet.The receiving physician's clinical diagnosisis diabetic ketoacidosis (DKA). Furtherinvestigations revealed: plasma glucose isvery high (often>40 mmol/L), along withraised urea and creatinine. With the patient'scondition, discuss the biochemistry why shebecame hypovolemic?

Hereditary spherocytosis is an inherited disease of red blood cells in which red blood cells are…

Answered: concentration (MCHC) in a patient…

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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Discuss the pathology of a condition in which glucose regulation (in the blood and/or urine) presents problems for patients. What causes this condition? How is glucose monitoring accomplished, and how is it indicative of the patient's level of proper biological function? Explain on a cellular level how this glucose imbalance arises. Also explain the science behind the monitoring technique. Most importantly, what measures can be taken by patients to correct for this glucose imbalance in the long term? Why do these measures work?
A child exhibits clear symptoms during infections or after vigorous exercise indicating hypoglycemia (low blood sugar) as well as increased levels of lactic acid in the blood, and may initially show as shakiness, irritability or even lethargy. The child has a diet similar to other children, so that is not the problem; however, it is noted that diet supplementation with the amino acid alanine is an effective treatment when symptoms show. Explain at least two possible metabolic rationales including what and how enzymes might be affected and their metabolic and physiological effects producing this individual’s condition.
Please state if the statements are true or false. 1. Erythrulose is a ketopentose2. The conversion of 1 mole of malate to 1 mole oxaloacetate produces 1 mole of NADH
31. A 6-year-old boy is brought to the physician by his mother because of intermittent upper abdominal pain during the past 5 weeks and a rash for 1 week. Vital signs are norma Physical examination shows yellow nodules over the extensor surfaces of the upper extremities. There is hepatomegaly and tenderness on palpation of the epigastric regior Serum studies show an increased amylase activity, increased chylomicron concentration, and a markedly increased triglyceride concentration. Three months after beginning restricted diet, his serum chylomicron and triglyceride concentrations decrease significantly, and the skin lesions resolve. A deficiency of which of the following enzymes is likely cause of these findings? O A) Acetyl-CoA carboxylase O B) HMG-CoA lyase O C) HMG-CoA reductase O D) Hormone-sensitive lipase O E) Lipoprotein lipase
You went on an Alaskan cruise. Great trip but you seem to have brought the "stomach flu" back with you and now you have been repeatedly and uncontrollably vomiting. What acid-base disturbance are you now at risk of developing? A few hours later, the vomiting has stopped, thank GOD, but now you're enjoying explosive watery diarrhea. Will this just add to the previous potential acid-base problem or might it help correct it?
What would happen to the patient if the serum cholinesterase activity were only 10 units of activity per liter rather than the normal activity of about 80 units?
Formulate a one-day meal plan for a 35-year-old male with a TCR of 2,000 kcal using the following distribution. Carbohydrates: 55% Fats: 20% Proteins: 25%
Is it possible for someone poisoned with cyanide to benefit from artificial respiration or oxygenation (i.e., giving them oxygen)? Explain why or why
Hemoglobin molecules exposed to high levels of glucose are converted to glycated products. The glycated product used to measure blood glucose control in diabetics is hemoglobin A1C (HbA1C), contained in red blood cells that last around 3 months. In general terms, explain how HbA1C forms and why it is a useful marker for blood glucose control.
Glucose has been found to react nonenzymatically with hemoglobin, through Schiff base formation between C-1 of glucose and the amino termini of the β chains. How might this finding be applied in monitoring diabetic patients?
104. A 32-year-old man is brought to the emergency department by ambulance 30 minutes after he was found unresponsive by his wife. Paramedics say that his blood glucose concentration was 22 mg/dL by fingerstick at the scene. He became responsive following administration of an ampule of 50% dextrose. On arrival, he says that he has a 3-month history of episodes of sweating and feeling shaky. His symptoms resolve when he eats a candy bar. Physical examination shows no abnormalities. The tentative diagnosis of insulinoma is made. In addition to a decreased glucose concentration, which of the following sets of findings in this patient during a fasting-induced hypoglycemic episode is most likely to confirm the diagnosis? A) B) C) D) E) F) Serum C Peptide ↑ Insulin 1 ↓ Urine Ketones present absent present absent present absent

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