How does hydroxyurea therapy alleviate the symptoms of sicklecell anemia?(Select all that apply.)HbS dilutes HbF and thus somewhat relieves thesymptoms of the disease.HbF dilutes HbS and thus somewhat relieves thesymptoms of the disease.HbF, because of its amino acid sequence, does notsickle and clog capillaries.O Hydroxyurea enhances the production of sickle-cellhemoglobin (HbS) in the bone marrow.Hydroxyurea enhances the production of fetalhemoglobin (HbF) in the bone marrow.O HbS, because of its amino acid sequence, does notsickle and clog capillaries.

The question is about therapy that allevate the treatment for sickle cell anaemia, the hydroxyurea…

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Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Which of the following is NOT a blood group antigenic determinants? L-fucose D-fucose beta-D-N-acetylglucosamine beta-D-N-acetylgalactosamine Which of the following represents an aldopentose? OH OH H. O но, но но- но- HO H но- но но -H H. H- -OH H- -OH -OH -O- OH но ÓH но HO он ÓH II II IV V The six groups of enzymes are the following: I. Oxidoreductases II. Transferases III. Hydrolases IV. Isomerases V. Lyases VI. Ligases Fill in the blanks: catalyze transfers of groups while catalyze bond breakages. Il and V Il and VI V and II IV and II Il and IV Which of the following statements regarding the physical properties of triacylglycerol is FALSE? -In general, the melting point of a triacylglycerol increases as the degree of unsaturation increases. -In general, the melting point of a triacylglycerol decreases as the degree of unsaturation increases. -In general, the melting point of a triacylglycerol increases as the number of carbons in the hydrocarbon chain increases. -In general,…
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Pharmacodynamic (PD) Response Biomarkers Instructions Group (https://www.ncbi.nlm.nih.gov/books/NBK326791/), a biomarker is used to show that a biological response has occurred in an individual who has been exposed to a medical product or an environmental agent. Match the pharmacodynamic/response biomarker on the left, with the related you can use internet search, FDA According to the FDA-NIH Biomarker Working treatment/disease on the right. Please note that and NIH websites, as well as the on-line library resources. Sweat chloride Response to warfarin treatment International Effect of enzyme replacement therapy for patients with mucopolysaccharidosis type 1 normalized ratio (INR) Response to a B-lymphocyte stimulator inhibitor in patients with systemic lupus erythematosus Viral load Urinary level of glycosaminoglycans Response to cystic fibrosis transmembrane regulator (CFTR) potentiating agents in patients with cystic fibrosis Blood pressure Response to antihyperglycemic agents or…
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Absorbed from the intestines into the blood, nitrites (NO2-) interact with the hemoglobin of the blood and block its respiratory function, turning part of the hemoglobin (HbFe2+) into methemoglobin (HbFe3+), unable to transfer oxygen from the lungs to tissues. With the formation of a large amount of methemoglobin, oxygen starvation of tissues occurs, which can cause damage to the central nervous system.10 to 20 % - of methemoglobin (HbFe3+) - asymptomatic cyanosis,20 to 50% of methemoglobin (HbFe3+) - hypoxia develop,> 50% of methemoglobin (HbFe3+) - the person will die.The body weight of the average person is 60 kg. Blood mass averages 8% of a person’s body weight; blood density ρ = 1,050 g/cm3, the hemoglobin (Hb) content in it is 14 g per 100 ml.molecular weight of hemoglobin 65-68 kg/mol (use 68 kg/mol for calculation). Assume that 1 mole of hemoglobin reacts with one mole of nitrite ion to form 1 NO molecule:HbFe2+ + NO2- → HbFe3+ + NOwill a 290 mg dose of sodium nitrite be…
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