Compound 3 below, called mycoepoxydiene, has been isolated from a marine fungus and has been shown to possess anti-cancer and anti-inflammatory properties. It contains an unusual oxygen-bridged cyclooctadiene skeleton. Both enantiomers of this compound were made in the laboratory. (Org. Lett. 2002, 4, 2941-2943). Show the reagents you would use to convert compound 1 into compound 2. H3COCO,,, 1 OTBDMS CH3 2 A. conc. H₂SO4, heat D. 1) BH3-THF; 2) H₂O2, NaOH OTBDMS B. Br2 E. HBr CH3 C. H₂, Pt Many steps F. t-BuOK O 3 "O The transformation above can be performed with some combination of the reagents listed below. Give the necessary reagents in the correct order, as a string of letters (without spaces or punctuation, such as "EBF"). If there is more than one correct solution, provide just one answer. ""H CH3 CH3 TDBMS = -Si-t-Bu CH₂
Compound 3 below, called mycoepoxydiene, has been isolated from a marine fungus and has been shown to possess anti-cancer and anti-inflammatory properties. It contains an unusual oxygen-bridged cyclooctadiene skeleton. Both enantiomers of this compound were made in the laboratory. (Org. Lett. 2002, 4, 2941-2943). Show the reagents you would use to convert compound 1 into compound 2. H3COCO,,, 1 OTBDMS CH3 2 A. conc. H₂SO4, heat D. 1) BH3-THF; 2) H₂O2, NaOH OTBDMS B. Br2 E. HBr CH3 C. H₂, Pt Many steps F. t-BuOK O 3 "O The transformation above can be performed with some combination of the reagents listed below. Give the necessary reagents in the correct order, as a string of letters (without spaces or punctuation, such as "EBF"). If there is more than one correct solution, provide just one answer. ""H CH3 CH3 TDBMS = -Si-t-Bu CH₂
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Organomagnesium compounds
The interaction of alkyl halide with Mg metal in a suitable ether solvent is the common method for the synthesis of the Grignard reagent.
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Organomagnesium halides are Grignard reagents. Francois Auguste Victor Grignard, a French chemist who received the Nobel Prize in Chemistry in 1912, created these highly useful reagents.
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