Combinations of regulatory proteins control cell types MAT locus a2 at a2 a1 Expressed regulatory proteins a2 a1 a2 MCM1 MCM1 MCM1 a2 a2 a-specific genes ON OFF OFF MCM1 MCM1 MCM1 a1 a-specific genes OFF ON OFF MCM1 a1 a2 Haploid-specific ON ON OFF genes (a) a cell (b) a cell (c) ala cell FIGURE 12-10 Control of cell-type- specific gene expression in yeast. The three cell types of S. cerevisiae are determined by the regulatory proteins a1, a1, and a2, which regulate different subsets of target genes. The MCM1 protein acts in all three cell types and interacts with a1 and o2. In a diploid yeast cell, regulatory proteins encoded by each MAT locus are expressed (Figure 12-10c). What is the result? All the structural genes involved in cell mating are shut down, as are a separate set of genes, called haploid specific, that are expressed in haploid cells but not diploid cells. How does this happen? The a1 protein encoded by MAT has a part to play at last. The a1 protein can bind to some of the o2 protein present and alter its binding specificity such that the al-a2 com-
Combinations of regulatory proteins control cell types MAT locus a2 at a2 a1 Expressed regulatory proteins a2 a1 a2 MCM1 MCM1 MCM1 a2 a2 a-specific genes ON OFF OFF MCM1 MCM1 MCM1 a1 a-specific genes OFF ON OFF MCM1 a1 a2 Haploid-specific ON ON OFF genes (a) a cell (b) a cell (c) ala cell FIGURE 12-10 Control of cell-type- specific gene expression in yeast. The three cell types of S. cerevisiae are determined by the regulatory proteins a1, a1, and a2, which regulate different subsets of target genes. The MCM1 protein acts in all three cell types and interacts with a1 and o2. In a diploid yeast cell, regulatory proteins encoded by each MAT locus are expressed (Figure 12-10c). What is the result? All the structural genes involved in cell mating are shut down, as are a separate set of genes, called haploid specific, that are expressed in haploid cells but not diploid cells. How does this happen? The a1 protein encoded by MAT has a part to play at last. The a1 protein can bind to some of the o2 protein present and alter its binding specificity such that the al-a2 com-
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Question
Contrast the role of the MCM1 protein in different yeast
cell types shown in Figure 12-10. How are the a-specific
genes controlled differently in different cell types?
Transcribed Image Text:Combinations of regulatory proteins control cell types
MAT locus
a2
at
a2
a1
Expressed
regulatory
proteins
a2
a1
a2
MCM1
MCM1
MCM1
a2
a2
a-specific
genes
ON
OFF
OFF
MCM1
MCM1
MCM1
a1
a-specific
genes
OFF
ON
OFF
MCM1
a1 a2
Haploid-specific
ON
ON
OFF
genes
(a) a cell
(b) a cell
(c) ala cell
FIGURE 12-10 Control of cell-type-
specific gene expression in yeast. The
three cell types of S. cerevisiae are
determined by the regulatory proteins a1,
a1, and a2, which regulate different
subsets of target genes. The MCM1
protein acts in all three cell types and
interacts with a1 and o2.
In a diploid yeast cell, regulatory proteins encoded by each MAT locus are
expressed (Figure 12-10c). What is the result? All the structural genes involved in
cell mating are shut down, as are a separate set of genes, called haploid specific, that
are expressed in haploid cells but not diploid cells. How does this happen? The a1
protein encoded by MAT has a part to play at last. The a1 protein can bind to some
of the o2 protein present and alter its binding specificity such that the al-a2 com-
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