Clearly and neatly, draw a mechanism for the proposed synthesis of the anesthetic procaine (Novocain) in two (2) steps using p-nitrobenzoic nhydride (1) and N,N-diethylethanol amine (2). Be sure to note approximate equivalents for each reagent, solvents, all isolable intermediates conditions for isolation/purification of the final product. NOTE: A flow chart for purification might be extremely helpful. procaine (Novocain) O₂N 1

Clearly and neatly, draw a mechanism for the proposed synthesis of the anesthetic procaine (Novocain) in two (2) steps using p-nitrobenzoic nhydride (1) and N,N-diethylethanol amine (2). Be sure to note approximate equivalents for each reagent, solvents, all isolable intermediates conditions for isolation/purification of the final product. NOTE: A flow chart for purification might be extremely helpful. procaine (Novocain) O₂N 1

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

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Question

Clearly and neatly, draw a mechanism for the proposed synthesis of the anesthetic procaine (Novocain) in two (2) steps using p-nitrobenzoic acid
anhydride (1) and N,N-diethylethanol amine (2). Be sure to note approximate equivalents for each reagent, solvents, all isolable intermediates, and
conditions for isolation/purification of the final product. NOTE: A flow chart for purification might be extremely helpful.
YOL →
H₂N-
procaine (Novocain)
-NEt₂
O₂N
1
NO₂
HO
2
NEt₂

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