Chemical modifications of amino acids contribute to the diversity and function of proteins. For instance, γ-carboxylation of specific amino acids is required to make some proteins biologically active. What particular amino acid undergoes this modification, and what is its biological relevance? Warfarin, a derivative of coumarin, which is pres- ent in many plants, inhibits γ-carboxylation of this amino acid and was used in the past as a rat poison. At present, it is also used clinically in humans. What patients might be prescribed warfarin and why?
Chemical modifications of amino acids contribute to the diversity and function of proteins. For instance, γ-carboxylation of specific amino acids is required to make some proteins biologically active. What particular amino acid undergoes this modification, and what is its biological relevance? Warfarin, a derivative of coumarin, which is pres- ent in many plants, inhibits γ-carboxylation of this amino acid and was used in the past as a rat poison. At present, it is also used clinically in humans. What patients might be prescribed warfarin and why?
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Chemical modifications of amino acids contribute to the diversity and function of proteins. For instance, γ-carboxylation of specific amino acids is required to make some proteins biologically active. What particular amino acid undergoes this modification, and what is its biological relevance? Warfarin, a derivative of coumarin, which is pres- ent in many plants, inhibits γ-carboxylation of this amino acid and was used in the past as a rat poison. At present, it is also used clinically in humans. What patients might be prescribed warfarin and why?
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