Changing which pairs of the amino acids is most likely to directly lead to the most severe problems with substrate (Blue) binding by the protein depicted by the red ribbon.

Q: ADH1A alcohol dehydrogenase 1A (class I) Describe a way in which the gene can be manipulated to…

A: * The gene ADH1A alcohol dehydrogenase  gene encodes a member of the alcohol dehydrogenase family.…

Q: A biochemist is trying to determine the type of proteases they have isolated from walrus blubber.…

A: Enzymes are highly specialized proteins that have extraordinary catalytic power, greater than that…

Q: prpc is a normal protein of our neuronal cell membrane that is sensitive to protease action (ie can…

A: The proteases are the protein degrading enzymes. Once the role of proteinaceous enzymes and…

Q: A solution of peptide of unknown sequence was divided into 2 samples. One sample was tre with…

A: Site specific proteases are enzymes that cleaves polypeptide chains only at specific sites i.e. at…

Q: The distal histidine stabilises the iron in heme group of a deoxyhaemoglobin. T/F

A: Deoxyhemoglobin is a well studied protein because of its abundance in red blood cells. The main…

Q: Human serum transferrin is an iron transport protein. With the use of appropriate diagrams, describe…

A: Transferrin protein is a protein complex, which is known to transfer iron molecules to the cell.

Q: The S3’ pocket on PfSUB1 (attached) contains the side chains of Lys465 and Tyr427. Researchers…

A: According to Michaelis-Menten Kinetics, when the rate or velocity of an enzyme catalyzed reaction…

Q: Which one of the following would best allow us to conclude that the rate of chymotrypsin was…

A: Chymotrypsin is a serine protease enzyme that aids in digestion in several organisms including…

Q: a protein collected through affinity chromatography displays no activity even though it is found to…

A: Protein is made up of one or more amino acids that are linked together to form a chain. The building…

Q: Subjecting this peptide to trypsin would result in L-M-F-V-W-E-Q-A-P-S-P OA Lys and…

A: Trypsin is an enzyme that break peptide bond has a specific site of cleavage.

Q: Many proteins are secreted in their inactive form. This is also true of many toxic proteins produced…

A: A precursor of a protein, also known as a pro-peptide or pro-protein, is an inactive form of a…

Q: Discuss the Pharmacokinetics of morphine sulfate using the correct sequence you  have chosen in…

A: Morphine is a drug that targets a specific type of receptor that affects multiple processes. It does…

Q: Peptide YY (PYY) is a 36-amino acid peptide that is so named because it contains twobiochemically…

A: Peptide YY (PYY) is 36-amino-acid peptide and contains two biochemically relevant tyrosine residues

Q: In TLC, why are the colors of the peaks for each amino acid are different depending on the types of…

A: TLC stands for Thin Layer Chromatography. It is a refined technique that is used for isolating or…

Q: O- linked glycosylation of acceptor serine and threonine residues takes place in the golgi. true…

A: Some proteins undergo O-linked glycosylation in the golgi cisternae. The O-linked oligosaccharides…

Q: a protease that cleave peptide bonds adjacent to aspartate and glutamate would likely have an s1…

A: This statement is not entirely accurate. Proteases that cleave peptide bonds adjacent to aspartate…

Q: For answer (a) regarding the last row of compounds, why is the -CH-(CH3)2 not also responsible for…

A: Proteases are enzymes that cleave peptide bonds that link two amino acid residues together.…

Q: Y [S] Fig. 12.2 Graph of Y against [S], at fixed protein concentration, where the binding shows…

A: Allosteric regulation is a mode of regulation of an enzyme or other protein.  Allosteric activators…

Q: Why is the position of Cys 58  important in 3GRS(GLUTATHIONE REDUCTASE)? When Cys 58  is mutated to…

A: Dear Students, I have downloaded the PDB ID 3GRS structure from https://www.rcsb.org/ This is the…

Q: BIM-46187 is a protein inhibitor that binds to the a-subunit of the G. protein. It prevents the…

A: Cell signaling is the conversion of the information in a signal into cellular response. Ligands,…

Q: Explain why bacteria with the gene for the enzyme beta-lactamase are not susceptible to penicillin…

A: A beta-lactam ring is a four-membered lactam a cyclic amide, and beta-lactams are named so because…

Q: By definition, essential amino acids are not synthesized by an organism. Arginine is classified as…

A: Amino acids are the building blocks of amino acids which are broadly classified into two types based…

Q: It is important for a protease to distinguish between two different proteins so that it only cleaves…

A: The building blocks of proteins are organic substances called amino acids. They have a side chain (R…

Q: Describe the features of the first binding site (for allosteric enzyme unprotkb-p39086), including…

A: Answer ::   Ligands are the molecules that bind to a receptor and change the confirmation of the…

Q: Substrate A has a Km of 45uM and a kcat of 100/s with trypsin and a Km of 540mM and a kcat of 2/s…

A: Enzymes are the proteinous structure that helps in increasing the rate of metabolism. The function…

Q: Why is trypsin an unusual name for an enzyme? (What is the convention for enzyme names?)  .

A: The enzymes are the biocatalyst that perform specific biochemical reaction within the body and after…

Q: Trypsin cleaves proteins on the carboxyl side of lysine. Trypsin inhibitor has a lysine residue, and…

A: Introduction: An enzyme is the catalysts that increase the rate of reaction without undergoing any…

Q: The neighboring amino acid that TYR 368 interacts with is ILE 160. What are the properties of the…

A: Amino acids are natural mixes that contain amine and carboxyl functional groups, alongside a side…

Q: Enzymes are stereochemically specific; that is, they oftenconvert only one stereoisomeric form of…

A: enzymes are proteins that are made up of amino acids. Enzymes contain active sites. These active…

Q: f) Identify -R groups that: Are hydrophobic, hydrophilic and aromatic • Are the H-bond donors and…

A: In the study of peptides and proteins, understanding their structural and chemical properties is…

Q: The peptide Leu-Cys-Arg-Ser-Gln-Met is subjected to Edman degradation. After the first cycle of this…

A: Peptide refers to a chain of amino acids which contains about 2 to 50 amino acids. A peptide chain…

Q: A lipase enzyme has been isolated from a bacterium with a strong red color, found in industrial…

A: Enzymes are protein molecules that increase the rate of reaction by decreasing the activation…

Q: Briefly discuss the synthesis of selenocysteine amino acid.

A: Selenocysteine(Sec): It is the 21 st amino acid of the genetic code and this amino acid contains…

Q: please provide the structure of the enzyme's catalytic serine residue (as a monomer)

A: The catalytic serine residue in enzymes plays a crucial role in many biochemical reactions. The…

Q: When alanine undergoes transamination with oxaloacetate, alanine is first converted to alpha-keto…

A: Transamination undertaken by transaminases (also called aminotransferases)  is an example of…

Q: cytosol but those without this substance have concentrations of up to 50uM in the cytosol by the…

A: OmpF porin is a type of nonspecific protein that forms the pore at the outer membrane of bacteria…

Q: please draw a cysteine - lysine mechanism

A: Amino acids are the building blocks of the proteins. There are 20 amino acids which are commonly…

Q: Healthy Person: Galactose GALKI protein GALT protein Glucose GALE protein The three proteins work…

A: The term 'galactosemia' refers to disorders of galactose metabolism. It is a rare inherited…

Q: Consider the Ramachandran plot to answer both questions. Which observation most likely describes…

A: The proteins are polypeptide chains of amino acids. These amino acids are packed into protein…

Gene Interactions

When the expression of a single trait is influenced by two or more different non-allelic genes, it is termed as genetic interaction. According to Mendel's law of inheritance, each gene functions in its own way and does not depend on the function of another gene, i.e., a single gene controls each of seven characteristics considered, but the complex contribution of many different genes determine many traits of an organism.

Gene Expression

Gene expression is a process by which the instructions present in deoxyribonucleic acid (DNA) are converted into useful molecules such as proteins, and functional messenger ribonucleic (mRNA) molecules in the case of non-protein-coding genes.