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Question 8: The following table shows the glycolysis reactions and their standard Gibbs free energy changes at 25 C. Answer the following questions: A. What is the Gibbs free energy expression of the glycolysis pathway? B. What is the overall reaction of the glycolysis pathway? C. Suppose that the physiological concentrations of some metabolites are known as follows: micromolar Pyruvate 380 NADH 50 H* 0.1 ATP ? Glucose 3000 NAD+ 540 ADP ? Pi 3500 What should be the ATP:ADP ratio so that the glycolysis proceeds spontaneously at 25 C? The Reactions of Glycolysis and Their Standard Free-Energy Changes Step Enzyme AG kJ mol kcal mol Reaction Glucose + ATP → Glucose-6-phosphate + ADP Hexokinase/ Glucokinase -16.7 -4.0 Glucose-6-phosphate →Fructose-6-phosphate Fructose-6-phosphate + ATP → Fructose-l, 6-bisphosphate + ADP Fructose-1,6-bisphosphate Dihydroxyacetone phosphate + Glyceraldehyde-3-phosphate 2 Glucose phosphate isomerase +1.67 +0.4 3 Phosphofructokinase -14.2 -3.4 Aldolase +23.9 +5.7 Dihydroxyacetone phosphate→ Glyceraldehyde- 3-phosphate Triose phosphate isomerase +7.56 +1.8 2(Glyceraldehyde-3-phosphate + NAD* + P, → 1,3-bisphosphoglycerate + NADH + H") Glyceraldehyde-3-P dehydrogenase 2(+6.20) 2(+1.5) 7 Phosphoglycerate kinase 2(1,3-bisphosphoglycerate + ADP → 3-Phosphoglycerate + ATP) 2(-18.8) 2(-4.5) 2(3-Phosphoglycerate →2-Phosphoglycerate) Phosphoglyceromutase 2(+4.4) 2(+1.1) 9. 2(2-Phosphoglycerate - Phosphoenolpyruvate + H,O) Enolase 2(+1.8) 2(+0.4) 2(Phosphoenolpyruvate + ADP → Pyruvate + ATP) 10 Pyruvate kinase 2(-31.4) 2(-7.5)

Question 8: The following table shows the glycolysis reactions and their standard Gibbs free energy changes at 25 C. Answer the following questions: A. What is the Gibbs free energy expression of the glycolysis pathway? B. What is the overall reaction of the glycolysis pathway? C. Suppose that the physiological concentrations of some metabolites are known as follows: micromolar Pyruvate 380 NADH 50 H* 0.1 ATP ? Glucose 3000 NAD+ 540 ADP ? Pi 3500 What should be the ATP:ADP ratio so that the glycolysis proceeds spontaneously at 25 C? The Reactions of Glycolysis and Their Standard Free-Energy Changes Step Enzyme AG kJ mol kcal mol Reaction Glucose + ATP → Glucose-6-phosphate + ADP Hexokinase/ Glucokinase -16.7 -4.0 Glucose-6-phosphate →Fructose-6-phosphate Fructose-6-phosphate + ATP → Fructose-l, 6-bisphosphate + ADP Fructose-1,6-bisphosphate Dihydroxyacetone phosphate + Glyceraldehyde-3-phosphate 2 Glucose phosphate isomerase +1.67 +0.4 3 Phosphofructokinase -14.2 -3.4 Aldolase +23.9 +5.7 Dihydroxyacetone phosphate→ Glyceraldehyde- 3-phosphate Triose phosphate isomerase +7.56 +1.8 2(Glyceraldehyde-3-phosphate + NAD* + P, → 1,3-bisphosphoglycerate + NADH + H") Glyceraldehyde-3-P dehydrogenase 2(+6.20) 2(+1.5) 7 Phosphoglycerate kinase 2(1,3-bisphosphoglycerate + ADP → 3-Phosphoglycerate + ATP) 2(-18.8) 2(-4.5) 2(3-Phosphoglycerate →2-Phosphoglycerate) Phosphoglyceromutase 2(+4.4) 2(+1.1) 9. 2(2-Phosphoglycerate - Phosphoenolpyruvate + H,O) Enolase 2(+1.8) 2(+0.4) 2(Phosphoenolpyruvate + ADP → Pyruvate + ATP) 10 Pyruvate kinase 2(-31.4) 2(-7.5)

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
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Question 8: The following table shows the glycolysis reactions and their standard Gibbs free energy changes at 25 C. Answer the following questions: A. What is the Gibbs free energy expression of the glycolysis pathway? B. What is the overall reaction of the glycolysis pathway? C. Suppose that the physiological concentrations of some metabolites are known as follows:
Transcribed Image Text:Question 8: The following table shows the glycolysis reactions and their standard Gibbs free energy changes at 25 C. Answer the following questions: A. What is the Gibbs free energy expression of the glycolysis pathway? B. What is the overall reaction of the glycolysis pathway? C. Suppose that the physiological concentrations of some metabolites are known as follows:
micromolar Pyruvate 380 NADH 50 H* 0.1 ATP ? Glucose 3000 NAD+ 540 ADP ? Pi 3500 What should be the ATP:ADP ratio so that the glycolysis proceeds spontaneously at 25 C? The Reactions of Glycolysis and Their Standard Free-Energy Changes Step Enzyme AG kJ mol kcal mol Reaction Glucose + ATP → Glucose-6-phosphate + ADP Hexokinase/ Glucokinase -16.7 -4.0 Glucose-6-phosphate →Fructose-6-phosphate Fructose-6-phosphate + ATP → Fructose-l, 6-bisphosphate + ADP Fructose-1,6-bisphosphate Dihydroxyacetone phosphate + Glyceraldehyde-3-phosphate 2 Glucose phosphate isomerase +1.67 +0.4 3 Phosphofructokinase -14.2 -3.4 Aldolase +23.9 +5.7 Dihydroxyacetone phosphate→ Glyceraldehyde- 3-phosphate Triose phosphate isomerase +7.56 +1.8 2(Glyceraldehyde-3-phosphate + NAD* + P, → 1,3-bisphosphoglycerate + NADH + H") Glyceraldehyde-3-P dehydrogenase 2(+6.20) 2(+1.5) 7 Phosphoglycerate kinase 2(1,3-bisphosphoglycerate + ADP → 3-Phosphoglycerate + ATP) 2(-18.8) 2(-4.5) 2(3-Phosphoglycerate →2-Phosphoglycerate) Phosphoglyceromutase 2(+4.4) 2(+1.1) 9. 2(2-Phosphoglycerate - Phosphoenolpyruvate + H,O) Enolase 2(+1.8) 2(+0.4) 2(Phosphoenolpyruvate + ADP → Pyruvate + ATP) 10 Pyruvate kinase 2(-31.4) 2(-7.5)
Transcribed Image Text:micromolar Pyruvate 380 NADH 50 H* 0.1 ATP ? Glucose 3000 NAD+ 540 ADP ? Pi 3500 What should be the ATP:ADP ratio so that the glycolysis proceeds spontaneously at 25 C? The Reactions of Glycolysis and Their Standard Free-Energy Changes Step Enzyme AG kJ mol kcal mol Reaction Glucose + ATP → Glucose-6-phosphate + ADP Hexokinase/ Glucokinase -16.7 -4.0 Glucose-6-phosphate →Fructose-6-phosphate Fructose-6-phosphate + ATP → Fructose-l, 6-bisphosphate + ADP Fructose-1,6-bisphosphate Dihydroxyacetone phosphate + Glyceraldehyde-3-phosphate 2 Glucose phosphate isomerase +1.67 +0.4 3 Phosphofructokinase -14.2 -3.4 Aldolase +23.9 +5.7 Dihydroxyacetone phosphate→ Glyceraldehyde- 3-phosphate Triose phosphate isomerase +7.56 +1.8 2(Glyceraldehyde-3-phosphate + NAD* + P, → 1,3-bisphosphoglycerate + NADH + H") Glyceraldehyde-3-P dehydrogenase 2(+6.20) 2(+1.5) 7 Phosphoglycerate kinase 2(1,3-bisphosphoglycerate + ADP → 3-Phosphoglycerate + ATP) 2(-18.8) 2(-4.5) 2(3-Phosphoglycerate →2-Phosphoglycerate) Phosphoglyceromutase 2(+4.4) 2(+1.1) 9. 2(2-Phosphoglycerate - Phosphoenolpyruvate + H,O) Enolase 2(+1.8) 2(+0.4) 2(Phosphoenolpyruvate + ADP → Pyruvate + ATP) 10 Pyruvate kinase 2(-31.4) 2(-7.5)
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