Below is a modified scheme from a recent total synthesis of a certain anti-inflammatorycompound. Please provide the structures of A and B. Also, provide the acid-base equilibriumreaction between compound A and n-BuLi (CH3CH2CH2CH2L¡), showing pKa's of the acid andconjugate acid, as well as a properly drawn equilibrium arrow. Assume each reaction is followedwith a complete work-up.1.n-BuLi, then=-LiBrAÕTBSTHF, 60°C2. H2, Pd/PbO254%Br84%345 PSet 1..pdfW15

Alkynyllithium undergoes nucleophilic substitution with alkylhalide. H2/Pd, PbO2 reduces alkyne to…

Below is a modified scheme from a recent total synthesis of a certain anti-inflammatory compound. Please provide the structures of A and B. Also, provide the acid-base equilibrium reaction between compound A and n-BuLi (CH3CH2CH2CH2Lİ), showing pKa's of the acid and conjugate acid, as well as a properly drawn equilibrium arrow. Assume each reaction is followed with a complete work-up. 1. n-BuLi, then Br A ÖTBS THF, 60°C 84% 2. H2, Pd/PbO2 54% Br

Below is a modified scheme from a recent total synthesis of a certain anti-inflammatory compound. Please provide the structures of A and B. Also, provide the acid-base equilibrium reaction between compound A and n-BuLi (CH3CH2CH2CH2Lİ), showing pKa's of the acid and conjugate acid, as well as a properly drawn equilibrium arrow. Assume each reaction is followed with a complete work-up. 1. n-BuLi, then Br A ÖTBS THF, 60°C 84% 2. H2, Pd/PbO2 54% Br

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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Concept explainers

Amines

Amines are organic compounds with a nitrogen atom having a lone pair of electrons on it. They are derived from ammonia (NH3) wherein hydrogen atoms are substituted by an aryl or alkyl group.

Question

Below is a modified scheme from a recent total synthesis of a certain anti-inflammatory
compound. Please provide the structures of A and B. Also, provide the acid-base equilibrium
reaction between compound A and n-BuLi (CH3CH2CH2CH2L¡), showing pKa's of the acid and
conjugate acid, as well as a properly drawn equilibrium arrow. Assume each reaction is followed
with a complete work-up.
1.
n-BuLi, then
=-Li
Br
A
ÕTBS
THF, 60°C
2. H2, Pd/PbO2
54%
Br
84%
345 PSet 1..pdf
W
15

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