Based upon these results, which of the following factors and related processes is most likely controlled byYPI-1 and why?A. Clathrin and vesicle formation.B. Dynamin and vesicle scission.C. Auxilin and Hsc-70 and clathrin uncoating.D. Cargo loading (such as LDL and cholesterol).

Answered: Based upon these results, which of the…

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

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Question

Based upon these results, which of the following factors and related processes is most likely controlled by
YPI-1 and why?
A. Clathrin and vesicle formation.
B. Dynamin and vesicle scission.
C. Auxilin and Hsc-70 and clathrin uncoating.
D. Cargo loading (such as LDL and cholesterol).

Expert Solution

Step 1

Endocytosis: It is the process of internalization of external molecules into the cell. The molecule binds to the proteins in the cell membrane and internalized to form a pit. This is then pinched off from the plasma membrane as a vesicle.

Steps in clathrin-coated vesicle formation:

The external molecules bind to the proteins on the surface of the cell.
The adaptor proteins are recruited to the cell surface and polymerized. Clathrin is then recruited to the surface to coat the vesicles.
The external molecule is internalized by pit formation in the plasma membrane.
The dynamin which is a GTPase helps in constriction of vesicles from plasma membrane.
The clathrin is then uncoated from vesicles with the help of auxilin and hsc-70.

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