Barrier insulators stop the spread of heterochromatin HР-1 HMȚase HAT FIGURE 12-26 In this model, barier insulators recruit enzymatic activities such as histone acetyltransferase (HAT) that promote euchromatin formation. The letter "M" stands for methylation, and the letter "A" for acetylation. Heterochromatin Euchromatin Barrier insulator

Biochemistry
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ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
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Chapter1: Biochemistry: An Evolving Science
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In Figure 12-26, provide a biochemical mechanism for
why HP-1 can bind to the DNA only on the left side of the
barrier insulator. Similarly, why can HMTase bind only
to the DNA on the left of the barrier insulator?

Barrier insulators stop the spread of heterochromatin
HР-1
HMȚase
HAT
FIGURE 12-26 In this model, barier
insulators recruit enzymatic activities such
as histone acetyltransferase (HAT) that
promote euchromatin formation. The letter
"M" stands for methylation, and the letter
"A" for acetylation.
Heterochromatin
Euchromatin
Barrier
insulator
Transcribed Image Text:Barrier insulators stop the spread of heterochromatin HР-1 HMȚase HAT FIGURE 12-26 In this model, barier insulators recruit enzymatic activities such as histone acetyltransferase (HAT) that promote euchromatin formation. The letter "M" stands for methylation, and the letter "A" for acetylation. Heterochromatin Euchromatin Barrier insulator
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