B. To anesthetize a patient, there is a 10 ml bottle of Ketamine at a 10% concentration. If the dose of Ketamine in cats is 15 mg/Kg and the cat weighs 4 pounds. Calculate a) Weight of the cat in kg. b) mg of Ketamine needed to anesthetize the cat. c) Volume in ml of Ketamine. Answer: a) 1.82kg b) 27.3mg c) 0.27ml C. A 15-lb patient presents acute post-surgical pain. To treat the pain, there are ampoules of fentanyl at a concentration of 1mg/2ml. If the dose of fentanyl is 5µg/Kg, calculate a) the dose in mg of fentanyl needed for the patient and b) the volume in ml to be injected into the patient. Answer: = a) 0.034mg b) 0.06ml
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- SOLVE THE FOLLOWING PROBLEMS OF DOSE CALCULATION, SHOW THE CALCULATIONS FOR EACH OF THEY: 10. To anesthetize a patient, a 10 ml bottle of Ketamine is available at a concentration at 10% If the Ketamine dose in patients is 15 mg/Kg and the patient weighs 4 lbs. Calculate: a) Weight of the patient in Kg. b) mg of Ketamine needed to anesthetize the patient. c) Volume in ml of Ketamine.After oral administration of single 250 mg capsule of an antihypertensive drug to a normal volunteer, the total calculated AUC was 50 mg.hr/L. After intravenous bolus administration of 100 mg, the AUC was 100 hr/L. explain the way plz What is the the absolute bioavailability of the drug from the tablet applied orally? (10. SLAYT) A) 60 % B) 20 % C) 50 % D) 75 % E) 40 %1. Demonstrate the procedure for arriving at the answer. A. To anesthetize a patient, there is a 10 ml bottle of Ketamine at a 10% concentration. If the dose of Ketamine in cats is 15 mg/Kg and the cat weighs 4 pounds. Calculate a) Weight of the cat in kg. b) mg of Ketamine needed to anesthetize the cat. c) Volume in ml of Ketamine. Answer: a) 1.82kg b) 27.3mg c) 0.27ml B. A 15-lb patient presents acute post-surgical pain. To treat the pain, there are ampoules of fentanyl at a concentration of 1mg/2ml. If the dose of fentanyl is 5ug/Kg, calculate a) the dose in mg of fentanyl needed for the patient and b) the volume in ml to be injected into the patient. Answer: = a) 0.034mg b) 0.06ml
- 18. Esmolol 1.2 g in 500 mL D5W has been ordered at a rate of 100 mcg/kg/min for a client weighting 103.2 kg. Determine the following: a) dosage in mcg/min: b) rate in mL/hr c) Is the dosage administered to the client safe?After oral administration of single 100 mg capsule of an antihypertensive drug to a normal volunteer, the total calculated AUC was 20 mg.hr/L. After intravenous bolus administration of 20 mg, the AUC was 10 mg.hr/L. Calculate the absolute bioavailability of the drug from the tablet applied orally. (10. SLAYT) A) 60% B) 20% C) 40% D) 50% E) 75% What sould be the minimum solubility of an active substance (its molecular weight:500) in the dissolution media to be chosen in order to ensure the sink condition in the paddle method by using a 1 liter volume of beaker of a tablet (its dose strength is 100 mg and tablet weight is 200 mg? (4. SLAYT) 1 mg/ml 200 mg/ml 20 mg/ml 5 mg/ ml 10 mg/ mlAs a prescriber, you need to write a prescription for codeine syrup (25 mg/5 mL) for a patient with swallowing difficulties. You want to prescribe a sufficient amount to give a dose of 30 mg four times a day for 2 weeks. i) How much is required for the required dose? ii) How much is required for a two-week supply?
- Concentration (mg/L) Time (hours) Sustained-Release Tablet Oral Solution 0.5 2.26 19.80 1 4.57 18.31 1.5 5.27 15.49 2 6.73 12.37 7.36 9.62 4 7.40 6.85 5 7.50 5.52 6.24 3.10 8. 4.70 1.79 12 2.76 1.587) Elroscin 75 meq is ordered. This medicatiun is quailable in 0.025 025mg tablefs . How many tablets doyou give :A drug has been developed for oral administration as a rapidly dissolving capsule. This drug is also available as an intravenous formulation. Pharmacokinetic studies with both formulations in a relevant patient population provided the following values for absorption rate constant, clearance, volume of distribution and bioavailability: ka = 1.0 h-1; Cl = 9 L/h; V = 90 L; and F = 0.8. Calculate the drug concentration (in the blood) 8 h after a 1000 mg dose is administered orally.
- mL b) Order of Ex.12: Calculate the following injectable dosages. a) Order of dosage: Lasix 40 mg intramuscularly. Supply: Lasix 10 mg/mL Give: dosage: Atropine 0.4 mg intramuscularly one hour pre-operatively. Supply: Atropine 1/150 grain/mL (or 0.0067 grain/mL) Give: dosage: Valium 7.5 mg intramuscularly stat. Supply: Valium 10. mg/mL Give: _mL Ex.13: Use the given table to determine the following. 23.2 g ice mL c) Order of cm3 = g table salt 25.0 cm3 mL 102.2 g gold = g/mL mg/L Ex.14: A cube of metal has a mass of 14.6 g and its sides 3 = m3 density of ethanol = are 12.3 mm. What is the identity of this metal? cmAnswer the following step by step A) If Dalmane is available as 15 mg capsules, what dosage is given with 2 capsules? B) Using 0.5 mg/kg of body weight for atropine by aerosol, what dose is needed for a 75-kg man? C) If Tempra is available as 120 mg/ 5 ml, how much dose is there in one-half teaspoon?b) -strength Ensure 16 oz by nasogastric (NG) tube over 8 hr. c) -strength Ensure 20 oz by gastrostomy tube (GT) over 5 hr. For each of the following, determine the rate in milliliters per hour for the following continuous feodings. Round answers to the nearest whole number. Use the formula m. ordered rate in ml hr. d) Ensure 480 mL by NG tube over 8 hr. Follow wih 100 ml, of water after each feeding e) Perative 1,600 mL over 24 hr. by gastrostomy. Follow w ith 250 ml of water