18. Esmolol 1.2 g in 500 mL DSW has been ordered at a rate of 100 mcg/kg/min for a client weighting 103.2 kg. Determine the following: a) dosage in mcg/min: b) rate in mL/hr c) Is the dosage administered to the client safe?
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- KCI for injection contains 40 mEq in 20 mL. An order requires 15 mEq, how many mL are needed?After oral administration of single 250 mg capsule of an antihypertensive drug to a normal volunteer, the total calculated AUC was 50 mg.hr/L. After intravenous bolus administration of 100 mg, the AUC was 100 hr/L. explain the way plz What is the the absolute bioavailability of the drug from the tablet applied orally? (10. SLAYT) A) 60 % B) 20 % C) 50 % D) 75 % E) 40 %A 65 kg patient is diagnosed with a stemi is to receive an IV bolus dose of abciximab 0.25mg/kg followed by a maintenance infusion of the drug at the rate of 0.125mcg/kg/min. The abciximab is available in 5mL vials containing 2mg/mL. a) How many mL will you administer for the bolus? b) How many mcg/min will the patient receive during the maintenance infusion?
- A 40kg child has been prescribed an initial loading dose of warfarin 0.2mg/kg PO. Warfarin is available in 1mg, 2mg, 2.5mg, 3mg, 4mg, 5mg, 6mg, 7.5mg and 10mg scored tablets. a) How many mg will the child receive, and which tablet strength would you use? b) On day 2, the INR comes back at 2.5 with a dosing protocol to reduce dose to 50% of the initial loading dose. How many mg would you administer, and which tablet strength would you use?A 6YO 44lb child has been prescribed an initial loading dose of warfarin 0.2mg/kg PO. Warfarin is available in 1mg, 2mg, 2.5mg, 3mg, 4mg, 5mg, 6mg, 7.5mg, 10mg scored tablets. a) How many mg will the child receive, and which tablets strength would you use? b) On day 2, the INR comes back at 3.2 with a dosing protocol to reduce tdose to 25% of the initial loading dose. How many mg would administer, and which tablet strength would you use?After oral administration of single 100 mg capsule of an antihypertensive drug to a normal volunteer, the total calculated AUC was 20 mg.hr/L. After intravenous bolus administration of 20 mg, the AUC was 10 mg.hr/L. Calculate the absolute bioavailability of the drug from the tablet applied orally. (10. SLAYT) A) 60% B) 20% C) 40% D) 50% E) 75% What sould be the minimum solubility of an active substance (its molecular weight:500) in the dissolution media to be chosen in order to ensure the sink condition in the paddle method by using a 1 liter volume of beaker of a tablet (its dose strength is 100 mg and tablet weight is 200 mg? (4. SLAYT) 1 mg/ml 200 mg/ml 20 mg/ml 5 mg/ ml 10 mg/ ml
- Mrs B, aged 43 years, weight 56 kg, requires a loading dose of drug B. The target plasma concentration is 18.9 mg/ L, volume of distribution is 0.5 L/ kg, the salt factor is 0.9 and bioavailability fraction is 1. What is the intravenous loading dose (LD) of Drug B in milligrams (mg)? units - mg LD = Cp desired x Vd S x F Where Cp desired is the target plasma concentration; Vd is the volume of distribution; S is the salt factor and F is the bioavailability fractionAn order reads: Daptomycin in NS IV Administer 8 mg/kg over 30 min q24 hrs x 10 days How many milliliters of a vial containing 500 mg of daptomycin in 10 mL should be added to a 100 mL bag of NS to follow the order above to treat a 245-lb patient?mL b) Order of Ex.12: Calculate the following injectable dosages. a) Order of dosage: Lasix 40 mg intramuscularly. Supply: Lasix 10 mg/mL Give: dosage: Atropine 0.4 mg intramuscularly one hour pre-operatively. Supply: Atropine 1/150 grain/mL (or 0.0067 grain/mL) Give: dosage: Valium 7.5 mg intramuscularly stat. Supply: Valium 10. mg/mL Give: _mL Ex.13: Use the given table to determine the following. 23.2 g ice mL c) Order of cm3 = g table salt 25.0 cm3 mL 102.2 g gold = g/mL mg/L Ex.14: A cube of metal has a mass of 14.6 g and its sides 3 = m3 density of ethanol = are 12.3 mm. What is the identity of this metal? cm
- 7) Elroscin 75 meq is ordered. This medicatiun is quailable in 0.025 025mg tablefs . How many tablets doyou give :A 100 ml vial of alteplase, a thrombolytic drug, contains 100 mg of drug equivalent to 58,000,000 international units to be administered via intravenous infusion. Determine the units administered to a patient who weighs 172 lb at a dose of 0.9 mg/kg and the volume of injection to use. 43,100,200 units: 78.60 mL 50,810,000 units: 75.50 mL O45,500,700 units: 73.80 mL 40,808,800 units: 70.40 mLA drug has been developed for oral administration as a rapidly dissolving capsule. This drug is also available as an intravenous formulation. Pharmacokinetic studies with both formulations in a relevant patient population provided the following values for absorption rate constant, clearance, volume of distribution and bioavailability: ka = 1.0 h-1; Cl = 9 L/h; V = 90 L; and F = 0.8. Calculate the drug concentration (in the blood) 8 h after a 1000 mg dose is administered orally.