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B. Ink proteins bind to and inhibit one of the cdk's in the cell cycle. (Ink = INhibitor of Kinase.) Many cancer cells have mutations in the INK gene(s). (For clarity, the protein name is given in lower case and the gene name in upper case.) Some cancer cells have normal INK genes but have mutation(s) in the corresponding CDK gene(s) that eliminate cdk-ink protein binding. (Other aspects of cdk function are normal.) Given this information, what would you expect? B-1. Levels of ink activity in tumor cells with mutations in the INK gene should be (normal) (above normal) (below normal) (can't predict). B-2. Levels of ink activity in tumor cells with mutations in the CDK gene should be (normal) (above normal) (below normal) (can't predict).

B. Ink proteins bind to and inhibit one of the cdk's in the cell cycle. (Ink = INhibitor of Kinase.) Many cancer cells have mutations in the INK gene(s). (For clarity, the protein name is given in lower case and the gene name in upper case.) Some cancer cells have normal INK genes but have mutation(s) in the corresponding CDK gene(s) that eliminate cdk-ink protein binding. (Other aspects of cdk function are normal.) Given this information, what would you expect? B-1. Levels of ink activity in tumor cells with mutations in the INK gene should be (normal) (above normal) (below normal) (can't predict). B-2. Levels of ink activity in tumor cells with mutations in the CDK gene should be (normal) (above normal) (below normal) (can't predict).

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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15-13. You are working in a laboratory on an independent study project. You have some epithelial cells from a human growing in a bottle. These cells normally divide throughout life. Before spring break, you replaced the medium (fluid surrounding the cells) with fresh medium and forgot to include any growth factors. Then you went home for spring break. A-1. Now that you have come back after vacation, you will probably find that the cells have (grown normally) (arrested at G1/S) (arrested at S/G2) (arrested at G2/M) (grown much more than usual) AND A-2. When you add the missing growth factor to the medium, the cells will probably start to synthesize (p53) (growth factor receptor) (MPF) (cyclin) (cdk = cyclin dependent kinase) (none of these). B. Ink proteins bind to and inhibit one of the cdk's in the cell cycle. (Ink = INhibitor of Kinase.) Many cancer cells have mutations in the INK gene(s). (For clarity, the protein name is given in lower case and the gene name in upper case.) Some cancer cells have normal INK genes but have mutation(s) in the corresponding CDK gene(s) that eliminate cdk-ink protein binding. (Other aspects of cdk function are normal.) Given this information, what would you expect? B-1. Levels of ink activity in tumor cells with mutations in the INK gene should be (normal) (above normal) (below normal) (can't predict). B-2. Levels of ink activity in tumor cells with mutations in the CDK gene should be (normal) (above normal) (below normal) (can't predict).
Transcribed Image Text:15-13. You are working in a laboratory on an independent study project. You have some epithelial cells from a human growing in a bottle. These cells normally divide throughout life. Before spring break, you replaced the medium (fluid surrounding the cells) with fresh medium and forgot to include any growth factors. Then you went home for spring break. A-1. Now that you have come back after vacation, you will probably find that the cells have (grown normally) (arrested at G1/S) (arrested at S/G2) (arrested at G2/M) (grown much more than usual) AND A-2. When you add the missing growth factor to the medium, the cells will probably start to synthesize (p53) (growth factor receptor) (MPF) (cyclin) (cdk = cyclin dependent kinase) (none of these). B. Ink proteins bind to and inhibit one of the cdk's in the cell cycle. (Ink = INhibitor of Kinase.) Many cancer cells have mutations in the INK gene(s). (For clarity, the protein name is given in lower case and the gene name in upper case.) Some cancer cells have normal INK genes but have mutation(s) in the corresponding CDK gene(s) that eliminate cdk-ink protein binding. (Other aspects of cdk function are normal.) Given this information, what would you expect? B-1. Levels of ink activity in tumor cells with mutations in the INK gene should be (normal) (above normal) (below normal) (can't predict). B-2. Levels of ink activity in tumor cells with mutations in the CDK gene should be (normal) (above normal) (below normal) (can't predict).
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