(b) Answer ALL parts (i)-(iv) of this question. The scheme below outlines a synthesis of a vitamin A analogue. (i) Suggest reagents for the conversion of 1 into 2 and write a mechanism for this reaction; (ii) Suggest a reagent for the conversion of 3 into 4; (iii) Propose a mechanism for the conversion of 4 into 5; (iv) Suggest reagents for the conversion of 5 into 6 and provide a mechanism for this transformation. reagents? 2 reagents? PPH3; HBr ÓH 3 PPH3 Br reagents? 5

(b) Answer ALL parts (i)-(iv) of this question. The scheme below outlines a synthesis of a vitamin A analogue. (i) Suggest reagents for the conversion of 1 into 2 and write a mechanism for this reaction; (ii) Suggest a reagent for the conversion of 3 into 4; (iii) Propose a mechanism for the conversion of 4 into 5; (iv) Suggest reagents for the conversion of 5 into 6 and provide a mechanism for this transformation. reagents? 2 reagents? PPH3; HBr ÓH 3 PPH3 Br reagents? 5

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

See similar textbooks

Similar questions

(iii) Rank the carbonyl compounds given below in terms of their relative reactivity with sodium borohydride. RT R CH3 CI (iv) Suggest two factors which combine to make the aldehyde react with sodium borohydride at a different rate from the ketone. (v) Based on electronegativity one might assume that the ester and acid chloride possess similar reactivity towards nucleophiles. Suggest why this turns out not to be the case (your answer should mention resonance and inductive effects).
Propose a synthesis for esmolol from 4-hydroxycinnamic acid, epichlorohydrin, and isopropylamine
Addition of weak base, such as pyridine, to a solution of 4 in ethanol affords A in essentially quantitative yield. Suggest a structure for A and provide a reaction mechanism for its formation. t-Bu-N 4 C8H13 NO2 pyridine A C16H24N2O3
Propose stepwise mechanisms for the following reactions.
Within each structure, rank the indicated nitrogens by increasing basicity. Explain all (guide line: Increasing basicity. Begin by identifying the classification of the nitrogen.) (b) nicotine cyamemaine, an anti-psychotic drug Pentenyl cation Pentenyl anion (d) HN LY (a) C₂H₂CH-N-C,H, LSD CH₂0. Which of these belong to MO of Vin ,t-pentadienyl? Ponlenyl radical CH₂ H (e) CH-C) HN utabrine (anti-malarial) ipsapirone, an anxiolytic drug 8888 81818 - Which of these belong to HOMO in ,,-heptatrienyl radical? And how many electron/s it has? two e, one e two e, one e, - Construct a qualitative MO diagram for the following systems and discuss how the MOS are modified by addition of the substituent (each ¹ mark) a) CH=CH-CH=CH compared to CH=CH-CHO Acrolein (propenal) NET₂ NHỊCH, b) CH=CH-CN compared to CH=CH-COOH c) CH=CH-F compared to CH=CH-NH - Comparing FMO of the given compounds with each other while doing reaction with a nucleophile and electrophile a) CH=CH-CH=CH, compared to CH=CH-CHO…
(4) Provide the reagents necessary to carry out the following synthesis. + enantiomer (A) (1) (i) BH3, (ii) H₂O2, NaOH; (2) NaOEt JATOT (B) (1) (i) BH3, (ii) H₂O2, NaOH; (2) TsCl, pyridine; (3) KOC(CH3)3 (C) (1) H3O+, (2) TsCl, pyridine, (3) KOC(CH3)3 (D) (1) HBr (no peroxides); (2) NaOEt
Each of the following is a set of directions for carrying out a reaction or sequence of reactions. Rewrite each set ofdirections in the form of a synthesis.(a) To 2-ethylcyclohexanone, add lithium diisopropylamide, and when that reaction is complete, add bromoethane toyield 2,6-diethylcyclohexanone.(b) Add molecular bromine to 2,2-dimethylcyclohexanone in the presence of acetic acid to yield 6-bromo-2,2-dimethylcyclohexanone. To the resulting mixture, add sodium cyanide to yield 6-cyano-2,2-dimethyl-cyclohexanone.(c) Treat pent-4-ynoic acid with diazomethane to produce methyl pent-4-ynoate. Next, add sodium hydride, followed by(bromomethyl)benzene, to yield methyl 6-phenylhex-4-ynoate.
(a) What reagents would be used for the conversion of alkene A into the target? (b) What reaction is involved in the conversion of alcohol B into alkene A? Suggest a reagent that might affect this transformation. (c) Give a retrosynthetic analysis showing the disconnection of B, the synthons produced that lead to the synthetic equivalents given (draw their structures).
how to slove this question?
(c) Outline the mechanism for the bromination of 3-methylcyclobutene.
2. (a) Ozonolysis of compound A, C,H12 gave two products B and C. Further analysis of these two compounds of B and C, showed positive results with 2,4-dinitrophenylhydrazine. Compound B reacts with Tollens' reagent while compound C does not indicate any positive result to the same reagent. However, both B and C gave same positive results with iodoform test. (i) By writing all the chemical equations involved, identify A, B and C.
(a) What product would you expect from cleavage of tetrahydrofuran with HI? (b) Outline a mechanism for the reaction.