Autosomal Dominant Disorder: Huntington's Disease 1. Huntington's disease is a neurological disease affecting humans. It has a late-onset and symptoms include involuntary muscle movements due to degeneration of the nervous system. Huntington's Disease is an autosomal dominant genetic disorder. A woman with the phenotype of Huntington's disease and the genotype Hh has children with a man with a normal (no Huntington's Disease) phenotype and the genotype hh. What are the chances that a particular child will have Huntington's Disease? a. Phenotypes of the parents: Mother: b. Genotypes of the parents: c. Gamete genotype(s): d. Punnett Square: (egg) Mother: Egg: (sperm) Father: Father: Sperm : e. List all possible genotypes of offspring of these parents: a. Which of these genotypes are heterozygous? b. Which of these genotypes are homozygous? f. List all the possible phenotypes of offspring of these parents: g. Calculate the probability of each genotype and phenotype as listed. Fill in table below on the following page.
Autosomal Dominant Disorder: Huntington's Disease 1. Huntington's disease is a neurological disease affecting humans. It has a late-onset and symptoms include involuntary muscle movements due to degeneration of the nervous system. Huntington's Disease is an autosomal dominant genetic disorder. A woman with the phenotype of Huntington's disease and the genotype Hh has children with a man with a normal (no Huntington's Disease) phenotype and the genotype hh. What are the chances that a particular child will have Huntington's Disease? a. Phenotypes of the parents: Mother: b. Genotypes of the parents: c. Gamete genotype(s): d. Punnett Square: (egg) Mother: Egg: (sperm) Father: Father: Sperm : e. List all possible genotypes of offspring of these parents: a. Which of these genotypes are heterozygous? b. Which of these genotypes are homozygous? f. List all the possible phenotypes of offspring of these parents: g. Calculate the probability of each genotype and phenotype as listed. Fill in table below on the following page.
Human Anatomy & Physiology (11th Edition)
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ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
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Transcribed Image Text:Autosomal Dominant Disorder: Huntington's Disease
1. Huntington's disease is a neurological disease affecting humans. It has a late-onset and
symptoms include involuntary muscle movements due to degeneration of the nervous system.
Huntington's Disease is an autosomal dominant genetic disorder. A woman with the
phenotype of Huntington's disease and the genotype Hh has children with a man with a
normal (no Huntington's Disease) phenotype and the genotype hh. What are the chances that
a particular child will have Huntington's Disease?
a. Phenotypes of the parents: Mother:
b. Genotypes of the parents:
c. Gamete genotype(s):
d. Punnett Square:
(egg)
Mother:
Egg:
(sperm)
Father:
Father:
Sperm :
e. List all possible genotypes of offspring of these parents:
a. Which of these genotypes are heterozygous?
b. Which of these genotypes are homozygous?
f. List all the possible phenotypes of offspring of these parents:
g. Calculate the probability of each genotype and phenotype as listed. Fill in table below on
the following page.
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