This is homework for a practice assessment. I need some assistance with these questions, so I can use them for studying material. Thank you so much! I highly appreciate it! 18. Carefully examine the figure below. Write figure captions that explain the mismatch DNA repairprocess below.Template strand withcorrect baseN6-methyladenineTemplateDNA strandCH3GATCCTAG5..3..5'Newly made DNA adeninewith incorrect baseUnmethylatedNewly madeDNA strandMuts binds to the mismatch.CH,GATCCTAG5'..3'3...5'5'-MutsMutHCH3MutL3"GATCCTAGMutS bound to mismatch5'forms a complex with MutLand MutH to bring theunmethylated GATC close tothe mismatch.MutsCH,GATCCTAG3'MutH nicks the unmethylatedDNA strand, and an exonucleaseexcises a section of the new DNAstrand, including the mismatch.5'CH,GATCCTAG3'DNA polymerase III and MutS binds to the mismatch.CH3GATCCTAG5'...3'3'..5'15'MutsMutHMutl3'GATCCTAGMutsMuts bound to mismatch5'forms a complex with MutLand MutH to bring theunmethylated GATC close tothe mismatch.CH,GATCCTAG3'MutH nicks the unmethylatedDNA strand, and an exonucleaseexcises a section of the new DNAstrand, including the mismatch.CH3GATCCTAG3"DNA polymerase III andligase repair the gap,producing the correct base pair.Copyright © 2006 Pearson Benjamin Cummings. All rights reserved.in

Answered: 18. Carefully examine the figure below.…

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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This is homework for a practice assessment. I need some assistance with these questions, so I can use them for studying material. Thank you so much! I highly appreciate it!

18. Carefully examine the figure below. Write figure captions that explain the mismatch DNA repair
process below.
Template strand with
correct base
N6-methyl
adenine
Template
DNA strand
CH3
GATC
CTAG
5..
3..
5'
Newly made DNA adenine
with incorrect base
Unmethylated
Newly made
DNA strand
Muts binds to the mismatch.
CH,
GATC
CTAG
5'..
3'
3...
5'
5'
-Muts
MutH
CH3
MutL
3"
GATC
CTAG
MutS bound to mismatch
5'
forms a complex with MutL
and MutH to bring the
unmethylated GATC close to
the mismatch.
Muts
CH,
GATC
CTAG
3'
MutH nicks the unmethylated
DNA strand, and an exonuclease
excises a section of the new DNA
strand, including the mismatch.
5'
CH,
GATC
CTAG
3'
DNA polymerase III and

MutS binds to the mismatch.
CH3
GATC
CTAG
5'...
3'
3'..
5'
15'
Muts
MutH
Mutl
3'
GATC
CTAG
Muts
Muts bound to mismatch
5'
forms a complex with MutL
and MutH to bring the
unmethylated GATC close to
the mismatch.
CH,
GATC
CTAG
3'
MutH nicks the unmethylated
DNA strand, and an exonuclease
excises a section of the new DNA
strand, including the mismatch.
CH3
GATC
CTAG
3"
DNA polymerase III and
ligase repair the gap,
producing the correct base pair.
Copyright © 2006 Pearson Benjamin Cummings. All rights reserved.
in

Expert Solution

Step 1

Mismatch repair

DNA mismatch repair is a system which is used for recognizing and repairing erroneous insertion, deletion and mis-substitution of bases which can arise during the process of DNA replication and recombination and repairing some forms of damaged DNA. It is a strand specific.

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