At pH 9.5, the charge on the side chain of Cys is
Biology 2e
2nd Edition
ISBN:9781947172517
Author:Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:Matthew Douglas, Jung Choi, Mary Ann Clark
Chapter3: Biological Macromolecules
Section: Chapter Questions
Problem 23CTQ: Amino acids have the generic structure seen below, where R represents different carbon-based side...
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Question
Can you please help find what the charge is?
![At pH 9.5, the charge on the side chain of Cys is
-1
+1](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2Feb7e2581-291c-405d-9e15-58ec27d07009%2Fedc46a7d-de91-412c-a5d0-0b9502af609d%2Ftyenix8_processed.jpeg&w=3840&q=75)
Transcribed Image Text:At pH 9.5, the charge on the side chain of Cys is
-1
+1
![Peptide lonization
Consider a peptide with the sequence Ser-His-Glu-Cys-Arg-Gln.
You will be asked to state the charge on the functional groups of this
peptide at pH 1 and pH 9.5.
You will also be asked to calculate the net charge on the peptide. You may
find it convenient to write down the charge on each group on a piece of
paper as you go along, so that you can add them up at the end.
Assume the following generic pK, values for ionizable functional groups:
a-carboxyl:
side-chain carboxyl:
imidazole:
3.1
4.1
6.0
a-amino:
8.0
thiol:
8.3
E-amino:
10.8
aromatic hydroxyl:
guanidino:
10.9
12.5](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2Feb7e2581-291c-405d-9e15-58ec27d07009%2Fedc46a7d-de91-412c-a5d0-0b9502af609d%2Fjw3yd1_processed.jpeg&w=3840&q=75)
Transcribed Image Text:Peptide lonization
Consider a peptide with the sequence Ser-His-Glu-Cys-Arg-Gln.
You will be asked to state the charge on the functional groups of this
peptide at pH 1 and pH 9.5.
You will also be asked to calculate the net charge on the peptide. You may
find it convenient to write down the charge on each group on a piece of
paper as you go along, so that you can add them up at the end.
Assume the following generic pK, values for ionizable functional groups:
a-carboxyl:
side-chain carboxyl:
imidazole:
3.1
4.1
6.0
a-amino:
8.0
thiol:
8.3
E-amino:
10.8
aromatic hydroxyl:
guanidino:
10.9
12.5
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