In humans, there are four typical modes of inheritance for Mendelian diseases: autosomal recessive, autosomal dominant, X-linked recessive, and X-linked dominant. For any pedigree, we may or may not be able to exclude some of these possibilities. Assume that no new mutations arise within the pedigrees-the disease-causing alleles are present from the start. a b c
In humans, there are four typical modes of inheritance for Mendelian diseases: autosomal recessive, autosomal dominant, X-linked recessive, and X-linked dominant. For any pedigree, we may or may not be able to exclude some of these possibilities. Assume that no new mutations arise within the pedigrees-the disease-causing alleles are present from the start. a b c
Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN:9781305251052
Author:Michael Cummings
Publisher:Michael Cummings
Chapter11: Genome Alterations: Mutation And Epigenetics
Section: Chapter Questions
Problem 16QP: Familial retinoblastoma, a rare autosomal dominant defect, arose in a large family that had no prior...
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a) Which of the four modes of inheritance are consistent with the disease shown in this human pedigrees below? (List the compatible mode or modes) Give an answer for a, b and c
b) If the parents in pedigree c have 2 other children, what is the probability that they will carry the disease?

Transcribed Image Text:In humans, there are four typical modes of inheritance for Mendelian diseases: autosomal
recessive, autosomal dominant, X-linked recessive, and X-linked dominant. For any pedigree, we
may or may not be able to exclude some of these possibilities. Assume that no new mutations arise
within the pedigrees-the disease-causing alleles are present from the start.
a
b
с
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Are any of them X-linked recessive or X-linked dominant?
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