Anisole undergoes demethylation to phenol by CYP450. Draw the full mechanism for the demethylation showing any intermediates that are formed in the reaction. The involvement of Fe should be shown, however, the haem structure and oxidation cycle for Fe in the CYP450 enzyme is is not required in this answer.

Anisole undergoes demethylation to phenol by CYP450. Draw the full mechanism for the demethylation showing any intermediates that are formed in the reaction. The involvement of Fe should be shown, however, the haem structure and oxidation cycle for Fe in the CYP450 enzyme is is not required in this answer.

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ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

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Designing a Synthesis

Organic synthesis is a branch of chemical synthesis that involves the planned construction of organic compounds/molecules from smaller units that possess functional groups. Friedrich Wöhler was the first scientist who designed the synthesis of an organic compound, urea from inorganic starting materials silver cyanate with ammonium chloride via a simple, one-step synthesis.

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Anisole undergoes demethylation to phenol by CYP450. Draw the full mechanism for the demethylation showing any
intermediates that are formed in the reaction. The involvement of Fe should be shown, however, the haem structure and
oxidation cycle for Fe in the CYP450 enzyme is is not required in this answer.

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