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a. Synthesizing glutamine is endergonic and so not spontaneous. How would having hese two reactions occur at the same time (likely by having an enzyme add a

a. Synthesizing glutamine is endergonic and so not spontaneous. How would having hese two reactions occur at the same time (likely by having an enzyme add a

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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2. One role of ATP is to facilitate reactions that would not occur spontaneously. The three phosphate groups are electron rich and tend to repel each other. Therefore, ATP is a bit like a compressed spring, ready to kick off one phosphate group releasing energy. Consider: Glutamic acid + NH3 ---> Glutamine ATP ---> ADP + Pi delta G= 3.4 kcal/mol delta G= -7.3 kcal/mol a. Synthesizing glutamine is endergonic and so not spontaneous. How would having these two reactions occur at the same time (likely by having an enzyme add a phosphate group from ATP to phosphorylate glutamic acid) energetically help with glutamine production? b. What is delta G for the combined reactions? c. Draw a simple energy diagram (showing energy of reactants and products) that shows why the glutamine reaction is not spontaneous. Then draw an energy diagram for the coupled reactions that shows why the combined reaction is favorable. d. Name a few of the biological processes in the body that require ATP?
Transcribed Image Text:2. One role of ATP is to facilitate reactions that would not occur spontaneously. The three phosphate groups are electron rich and tend to repel each other. Therefore, ATP is a bit like a compressed spring, ready to kick off one phosphate group releasing energy. Consider: Glutamic acid + NH3 ---> Glutamine ATP ---> ADP + Pi delta G= 3.4 kcal/mol delta G= -7.3 kcal/mol a. Synthesizing glutamine is endergonic and so not spontaneous. How would having these two reactions occur at the same time (likely by having an enzyme add a phosphate group from ATP to phosphorylate glutamic acid) energetically help with glutamine production? b. What is delta G for the combined reactions? c. Draw a simple energy diagram (showing energy of reactants and products) that shows why the glutamine reaction is not spontaneous. Then draw an energy diagram for the coupled reactions that shows why the combined reaction is favorable. d. Name a few of the biological processes in the body that require ATP?
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