Enzyme activity is dependent on many factors. List at least three different factors that could negatively impact enzyme activity and describe one use for each instance in the body. (I.E. Oxycontin binds to enzyme active sites responsible for transferring pain signals, thus would be considered a
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- n your own words and with your own diagrams, describe the catalytic reaction mechanism of the enzyme acetylcholinesterase. Discuss the functional roles of each member of the catalytic triad plus whatever other residues that you find important. Describe the actual movements of protons, and the making and breaking of bonds. What types of chemistries is the enzyme using? (what is the enzyme doing, in term of reactionRegarding the physical condition (characteristics of the solution/environment) in which an enzyme finds itself: sometimes enzymes are most active at a certain level and still active but to a lesser degree at a level above or below the optimal level. Describe the likely reason for the enzyme’s decrement in function at levels other than the optimal level?n a particular enzyme, an alanine residue is located in a cleft where the substrate binds. A mutation that changes this residue to glycine has little effect on activity; however, another mutation, which changes the alanine to a glutamate residue, leads to a complete loss of activity. Provide a brief explanation for these observation
- Allosteric activators block the active site, so the enzyme cannot bind True Or FalseEnzyme cofactors are usually inorganic ions that enhanceenzymatic activity by improving the “fit” between an enzymeand its substrate. True or false?Ingesting large amounts of glucose before a marathon might seem to be a good way of increasing the fuel stores. However, experienced runners do not ingest glucose before a race. What is the biochemical reason for their avoidance of this potential fuel? (Hint: Consider the effect of glucose ingestion on the level of insulin.)
- The blue structure in the diagram below is an enzyme. Please discuss what these diagrams (A and B) show. Please explain whether the grey tube within the enzyme would be effective as a drug or medication to inhibit this enzyme in both A and B. What type of drug or medication would this be called? A B ( ES ES OO #Allosteric regulation of an enzyme is accomplished when the enzyme pathway's product accumulates and then binds to the active (catalytic) site of the enzyme O True FalseA generalized enzyme active site is shaped like a hemisphere with a radius of 45Å. The active site holds the following amino acids in a homeostatic solution (pH = 7.38): -HAVARILKHAVARILKHAVARILK- Assuming the charge is distributed uniformly along the hemisphere, determine the force at which this active site acts upon a single ATP molecule at the center of the hemisphere.
- Which of these statements about enzyme-catalyzed reactions is false? The activation energy for the catalyzed reaction is the same as for the uncatalyzed reaction, but the equilibrium constant is more favorable in the enzyme-catalyzed reaction. The Michaelis-Menten constant Km equals the [S] at which V = 1/2 V, max: At saturating levels of substrate, the rate of an enzyme-catalyzed reaction is proportional to the enzyme concentration. The rate of a reaction decreases steadily with time as substrate is depleted. If enough substrate is added, the normal V, of max a reaction can be attained even in the presence of a competitive inhibitor.Please handraw this graph with all the necessary detailed information: Imagine that I text enzyme rate for four different temperatures: 10 degrees celsius, 20 degrees celsisus, 30 degree celsius, and 40 degree celsius, in separate tubes. The enzyme appears to work faster as temperature increases, but completely ceases activity at 40 degrees celcius. Sketch a graph to show this outcome, but here you will graph product formation (nmoles/mL) vs. time (minutes). The graph should be 4 lines and HANDDRAWN. Include a legend if necessary. You do not need precise quantitivate values, but most show the correct trends on the graph.Assume that an inhibitor (I) can bind to an enzyme and is modified by the enzyme. The modified inhibitor (I*) is then permanently associated with the active site of the enzyme, thus inhibiting the enzyme activity. Such inhibitors are called: Suicide substrates Transition-state analogs Both A and B Neither A nor Bwhich answer choice is correct im confused... thx