A young couple is planning to have children. Knowing that there have been a substantial number of stillbirths, miscarriages, and fertility problems on the husband’s side of the family, they see a genetic counselor. A chromosome analysis reveals that, whereas the woman has a normal karyotype, the man possesses only 45 chromosomes and is a carrier of a Robertsonian translocation between chromosomes 22 and 13. a. List all the different types of gametes that might be produced by the man. b. What types of zygotes will develop when each of gametes produced by the man fuses with a normal gamete produced by the woman? c. If trisomies and monosomies entailing chromosomes 13 and 22 are lethal, approximately what proportion of the surviving offspring are expected to be carriers of the translocation?
A young couple is planning to have children. Knowing that there have
been a substantial number of stillbirths, miscarriages, and fertility
problems on the husband’s side of the family, they see a genetic
counselor. A chromosome analysis reveals that, whereas the woman has
a normal karyotype, the man possesses only 45 chromosomes and is a
carrier of a Robertsonian translocation between chromosomes 22 and
13.
a. List all the different types of gametes that might be produced by the
man.
b. What types of zygotes will develop when each of gametes produced by
the man fuses with a normal gamete produced by the woman?
c. If trisomies and monosomies entailing chromosomes 13 and 22 are
lethal, approximately what proportion of the surviving offspring are
expected to be carriers of the translocation?
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