(a) Using the lecture entitled “On the Origin of life” by Jack Szostak. In one paragraph, summarize the conditions that  Szostak thinks led to the emergence of life on earth. (250 words maximum). (b) In one paragraph summarize the structure and function of biological membranes. Using the second article by Jack Szostak, "Protocells and RNA Self-Replication". Why is compartmentalization a prerequisite for evolution of life? Describe the ways in which protocells differ from cell membranes in evolved biological systems. (250 words maximum). Attached are images of the articles in question. Specific article links are: A) https://pubmed.ncbi.nlm.nih.gov/27576276/ b) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120706/

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(a) Using the lecture entitled “On the Origin of life” by Jack Szostak. In one paragraph, summarize the conditions that  Szostak thinks led to the emergence of life on earth. (250 words maximum).

(b) In one paragraph summarize the structure and function of biological membranes. Using the second article by Jack Szostak, "Protocells and RNA Self-Replication". Why is compartmentalization a prerequisite for evolution of life? Describe the ways in which protocells differ from cell membranes in evolved biological systems. (250 words maximum).

Attached are images of the articles in question.

Specific article links are:
A) https://pubmed.ncbi.nlm.nih.gov/27576276/

b) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120706/

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> Medicina (B Aires). 2016;76(4):199-203.
On the origin of life
Jack W Szostak 1
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PMID: 27576276
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Abstract
The origin of life is a very rich field, filled with possibilities and ripe for discovery. RNA replication
requires chemical energy and vesicle division is easy to do with mechanical energy. These
requirements point to a surface lake, perhaps at some time following the period of concentrated
cyanide chemistry that gave rise to nucleotides, amino acids and (maybe) fatty acids. A second
requirement follows specifically from the nature of the RNA replication cycle, which requires
generally cool to moderate temperatures for the copying chemistry, punctuated by brief periods of
high temperature for strand separation. Remarkably, lakes in a geothermal active area provide just
such a fluctuating temperature environment, because lakes similar to Yellowstone can be generally
cool (even ice covered in winter), but they contain numerous hydrothermal vents that emit streams
of hot water. Protocells in such an environment would occasionally be swept into these hot water
streams, where the transient high temperature exposure would cause RNA strand separation.
However, the protocells would be quickly mixed with surrounding cold water, and would therefore
cool quickly, before their delicate RNA molecules
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Transcribed Image Text:个 → C ▶https://pubmed.ncbi.nlm.nih.gov/27576276/ NIH National Library of Medicine National Center for Biotechnology Information PubMed® Advanced > Medicina (B Aires). 2016;76(4):199-203. On the origin of life Jack W Szostak 1 Affiliations + expand PMID: 27576276 Free article Save Email Abstract The origin of life is a very rich field, filled with possibilities and ripe for discovery. RNA replication requires chemical energy and vesicle division is easy to do with mechanical energy. These requirements point to a surface lake, perhaps at some time following the period of concentrated cyanide chemistry that gave rise to nucleotides, amino acids and (maybe) fatty acids. A second requirement follows specifically from the nature of the RNA replication cycle, which requires generally cool to moderate temperatures for the copying chemistry, punctuated by brief periods of high temperature for strand separation. Remarkably, lakes in a geothermal active area provide just such a fluctuating temperature environment, because lakes similar to Yellowstone can be generally cool (even ice covered in winter), but they contain numerous hydrothermal vents that emit streams of hot water. Protocells in such an environment would occasionally be swept into these hot water streams, where the transient high temperature exposure would cause RNA strand separation. However, the protocells would be quickly mixed with surrounding cold water, and would therefore cool quickly, before their delicate RNA molecules FULL TEXT LINKS Free Full Text medicina ACTIONS Send to Display options "Cite SHARE Search Collections f Log in PAGE NAVIGATION Abstract User Gu Cites < Title & authors Similar articles
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Journal List > Cold Spring Harb Perspect Biol > v.10(9); 2018 Sep > PMC6120706
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Cold Spring Harb Perspect Biol. 2018 Sep; 10(9): a034801.
doi: 10.1101/cshperspect.a034801
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Perspectives in Biology
Protocells and RNA Self-Replication
Gerald F. Joyce¹ and Jack W. Szostak²
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The general notion of an "RNA world" is that, in the early development of life on the Earth, genetic
continuity was assured by the replication of RNA, and RNA molecules were the chief agents of catalytic
function. Assuming that all of the components of RNA were available in some prebiotic locale, these
components could have assembled into activated nucleotides that condensed to form RNA polymers,
setting the stage for the chemical replication of polynucleotides through RNA-templated RNA
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Transcribed Image Text:→ C ➜ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120706/ An official website of the United States government Here's how you know NIH National Library of Medicine National Center for Biotechnology Information PMC PubMed Central® Journal List > Cold Spring Harb Perspect Biol > v.10(9); 2018 Sep > PMC6120706 Cold Spring Harb Perspect Biol Search PMC Full-Text Archive As a library, NLM provides access to scientific literature. Inclusion in an NLM database does not imply endorsement of, or agreement with, the contents by NLM or the National Institutes of Health. Learn more: PMC Disclaimer | PMC Copyright Notice Cold Spring Harb Perspect Biol. 2018 Sep; 10(9): a034801. doi: 10.1101/cshperspect.a034801 PERSPECTIVES CSH Cold Spring Harbor Perspectives in Biology Protocells and RNA Self-Replication Gerald F. Joyce¹ and Jack W. Szostak² SUMMARY ▸ Author information Copyright and License information ▶ PMC Disclaimer About Archive Subscribe Alerts Search in PMC PMCID: PMC6120706 PMID: 30181195 Go to: ► The general notion of an "RNA world" is that, in the early development of life on the Earth, genetic continuity was assured by the replication of RNA, and RNA molecules were the chief agents of catalytic function. Assuming that all of the components of RNA were available in some prebiotic locale, these components could have assembled into activated nucleotides that condensed to form RNA polymers, setting the stage for the chemical replication of polynucleotides through RNA-templated RNA OTHER FORMATS Advanced Search | User Guide PubReader | PDF (2.3M) ACTIONS Cite Collections SHARE f X RESOURCES Similar articles Cited by other articles Log in Links to NCBI Databases 12
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