A study published in the journal PLoS One (https://doi.org/10.1371/journal.pone.0217796) in 2019 presented results of a GWAS searching for loci impacting the risk of prolonged QRS in Hispanic/Latino people living in the U.S. QRS prolongation has been associated heart failure and cardiovascular mortality. The Manhattan plot below summarizes the results. The significance threshold for this study is shown as horizontal line at -log₁0(p-value) ~7.5. The names of candidate genes at each associated locus are shown at the top of the corresponding SNP tower. How many loci containing at least one
A study published in the journal PLoS One (https://doi.org/10.1371/journal.pone.0217796) in 2019 presented results of a GWAS searching for loci impacting the risk of prolonged QRS in Hispanic/Latino people living in the U.S. QRS prolongation has been associated heart failure and cardiovascular mortality. The Manhattan plot below summarizes the results. The significance threshold for this study is shown as horizontal line at -log₁0(p-value) ~7.5. The names of candidate genes at each associated locus are shown at the top of the corresponding SNP tower. How many loci containing at least one
Concepts of Biology
1st Edition
ISBN:9781938168116
Author:Samantha Fowler, Rebecca Roush, James Wise
Publisher:Samantha Fowler, Rebecca Roush, James Wise
Chapter10: Biotechnology
Section: Chapter Questions
Problem 13CTQ: Identify a possible advantage and a possible disadvantage of a genetic test that would identify...
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Question
![A study published in the journal PLoS One
(https://doi.org/10.1371/journal.pone.0217796) in 2019
presented results of a GWAS searching for loci impacting the risk
of prolonged QRS in Hispanic/Latino people living in the U.S.
QRS prolongation has been associated heart failure and
cardiovascular mortality. The Manhattan plot below summarizes
the results. The significance threshold for this study is shown as a
horizontal line at -log₁0 (p-value) ~7.5. The names of candidate
genes at each associated locus are shown at the top of the
corresponding SNP tower. How many loci containing at least one
gene affecting prolonged QRS risk were identified?
10
06
5
7
O 8
i
SCNSA-SCN10A
CDKN1A
HAND1 •
88
:
7 8
9
VTI1A
10
11
SYT1
MYOCD
LE
12 13 14 15 16 17 18 19 20 2122 X Y](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2Fb84de4bb-efe6-4583-9f2f-b3ca708ca3d6%2F19345825-3ec3-4a78-ba9a-253505cdc475%2Feo3bcu_processed.png&w=3840&q=75)
Transcribed Image Text:A study published in the journal PLoS One
(https://doi.org/10.1371/journal.pone.0217796) in 2019
presented results of a GWAS searching for loci impacting the risk
of prolonged QRS in Hispanic/Latino people living in the U.S.
QRS prolongation has been associated heart failure and
cardiovascular mortality. The Manhattan plot below summarizes
the results. The significance threshold for this study is shown as a
horizontal line at -log₁0 (p-value) ~7.5. The names of candidate
genes at each associated locus are shown at the top of the
corresponding SNP tower. How many loci containing at least one
gene affecting prolonged QRS risk were identified?
10
06
5
7
O 8
i
SCNSA-SCN10A
CDKN1A
HAND1 •
88
:
7 8
9
VTI1A
10
11
SYT1
MYOCD
LE
12 13 14 15 16 17 18 19 20 2122 X Y
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