A study published in the journal PLoS One(https://doi.org/10.1371/journal.pone.0217796) in 2019presented results of a GWAS searching for loci impacting the riskof prolonged QRS in Hispanic/Latino people living in the U.S.QRS prolongation has been associated heart failure andcardiovascular mortality. The Manhattan plot below summarizesthe results. The significance threshold for this study is shown as ahorizontal line at -log₁0 (p-value) ~7.5. The names of candidategenes at each associated locus are shown at the top of thecorresponding SNP tower. How many loci containing at least onegene affecting prolonged QRS risk were identified?100657O 8iSCNSA-SCN10ACDKN1AHAND1 •88:7 89VTI1A1011SYT1MYOCDLE12 13 14 15 16 17 18 19 20 2122 X Y

Answered: A study published in the journal PLoS…

Human Anatomy & Physiology (11th Edition)

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Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

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A study published in the journal PLoS One
(https://doi.org/10.1371/journal.pone.0217796) in 2019
presented results of a GWAS searching for loci impacting the risk
of prolonged QRS in Hispanic/Latino people living in the U.S.
QRS prolongation has been associated heart failure and
cardiovascular mortality. The Manhattan plot below summarizes
the results. The significance threshold for this study is shown as a
horizontal line at -log₁0 (p-value) ~7.5. The names of candidate
genes at each associated locus are shown at the top of the
corresponding SNP tower. How many loci containing at least one
gene affecting prolonged QRS risk were identified?
10
06
5
7
O 8
i
SCNSA-SCN10A
CDKN1A
HAND1 •
88
:
7 8
9
VTI1A
10
11
SYT1
MYOCD
LE
12 13 14 15 16 17 18 19 20 2122 X Y

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Step 1: Introduction.

Answer :- In a 2019 study published in the journal PLoS One, researchers conducted a Genome-Wide Association Study (GWAS) aimed at identifying loci that impact the risk of prolonged QRS duration in Hispanic/Latino individuals residing in the United States. Prolonged QRS duration is a critical marker associated with heart failure and cardiovascular mortality.

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