23,25 A study published in the journal PLoS One(https://doi.org/10.1371/journal.pone.0217796 ) in 2019 presented results ofa GWAS searching for loci impacting the risk of prolonged QRS inHispanic/Latino people living in the U.S. QRS prolongation has been associatedheart failure and cardiovascular mortality. The Manhattan plot belowsummarizes the results. The significance threshold for this study is shown as ahorizontal line at -log₁0(p-value) ~7.5. The names of candidate genes at eachassociated locus are shown at the top of the corresponding SNP tower. Howmany loci containing at least one gene affecting prolonged QRS risk wereidentified?-log10(p)C10-20SCN5A-SCN10A23CDKN1AHAND1678VTI1A20191011SYT1MYOCD:...12 13 14 15 16 17 18 19 20 2122 XY Two of the loci identified in the 2019 study were not identified in prior GWASstudies focused on this trait in people of European or African ancestry, andthose studies identified some loci not identified in this 2019 study ofHispanic/Latino people. Which of the following statements is the most likelyexplanation for these discrepancies?Some of the genes impacting prolonged QRS risk are different in people of differentancestry groupsPeople of Hispanic/Latino ancestry have a higher overall risk of prolonged QRSThe methodology employed in this study was flawedPeople of Hispanic/Latino ancestry have a lower overall risk of prolonged QRS

Answered: A study published in the journal PLoS…

Human Anatomy & Physiology (11th Edition)

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23,25

A study published in the journal PLoS One
(https://doi.org/10.1371/journal.pone.0217796 ) in 2019 presented results of
a GWAS searching for loci impacting the risk of prolonged QRS in
Hispanic/Latino people living in the U.S. QRS prolongation has been associated
heart failure and cardiovascular mortality. The Manhattan plot below
summarizes the results. The significance threshold for this study is shown as a
horizontal line at -log₁0(p-value) ~7.5. The names of candidate genes at each
associated locus are shown at the top of the corresponding SNP tower. How
many loci containing at least one gene affecting prolonged QRS risk were
identified?
-log10(p)
C
10-
2
0
SCN5A-SCN10A
2
3
CDKN1A
HAND1
6
7
8
VTI1A
201
9
10
11
SYT1
MYOCD
:
...
12 13 14 15 16 17 18 19 20 2122 XY

Two of the loci identified in the 2019 study were not identified in prior GWAS
studies focused on this trait in people of European or African ancestry, and
those studies identified some loci not identified in this 2019 study of
Hispanic/Latino people. Which of the following statements is the most likely
explanation for these discrepancies?
Some of the genes impacting prolonged QRS risk are different in people of different
ancestry groups
People of Hispanic/Latino ancestry have a higher overall risk of prolonged QRS
The methodology employed in this study was flawed
People of Hispanic/Latino ancestry have a lower overall risk of prolonged QRS

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Step 1: Introduction.

Answer :- Genome-Wide Association Studies (GWAS) play a crucial role in understanding the genetic basis of various traits and diseases. In a 2019 study published in the journal PLoS One, researchers conducted a GWAS to investigate loci impacting the risk of prolonged QRS duration in Hispanic/Latino individuals living in the United States. Prolonged QRS duration is a critical factor associated with heart failure and cardiovascular mortality. Surprisingly, this study identified loci that were not previously identified in GWAS studies focused on individuals of European or African ancestry, while some loci identified in those studies were not found in the Hispanic/Latino population. This discrepancy raises questions about the reasons behind such differences in findings.

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