A prospective groom, who is unaffected, has a sisterwith cystic fibrosis (CF), an autosomal recessive disease.Their parents are unaffected. The brother plans to marrya woman who has no history of CF in her family. Whatis the probability that they will produce a CF child? Theyare both Caucasian, and the overall frequency of CF inthe Caucasian population is 1/2500—that is, 1 affectedchild per 2500. (Assume the population meets the Hardy–Weinberg assumptions.)

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Mitochondrial Mutations

A mitochondrion is a cellular organelle that serves as the site for cellular respiration and energy production (ATP or Adenosine Triphosphate). It is a double-membrane-bound organelle and is only present in eukaryotic cells.