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A pioneer in designing and synthesizing antimetabolites that could destroy cancer cells was George Hitchings at the Burroughs Wellcome Company. In 1942, he initiated a pro- gram to discover DNA antimetabolites, and in 1948, he and Gertrude Elion synthesized 6-mercaptopurine, a successful drug for treating acute leukemia. Another DNA antime- tabolite synthesized by Hutchings and Elion was 6-thioguanine. Hitchings and Elion along with Sir James W. Black won the 1988 Nobel Prize in Physiology or Medicine for their discoveries of "important principles of drug treatment." In each drug, the oxygen at carbon 6 of the parent molecule is replaced by divalent sulfur. Draw structural formulas for the enethiol (the sulfur equivalent of an enol) forms of 6-mercaptopurine and 6-thioguanine. HN HN H,N H 6-Mercaptopurine 6-Thioguanine

A pioneer in designing and synthesizing antimetabolites that could destroy cancer cells was George Hitchings at the Burroughs Wellcome Company. In 1942, he initiated a pro- gram to discover DNA antimetabolites, and in 1948, he and Gertrude Elion synthesized 6-mercaptopurine, a successful drug for treating acute leukemia. Another DNA antime- tabolite synthesized by Hutchings and Elion was 6-thioguanine. Hitchings and Elion along with Sir James W. Black won the 1988 Nobel Prize in Physiology or Medicine for their discoveries of "important principles of drug treatment." In each drug, the oxygen at carbon 6 of the parent molecule is replaced by divalent sulfur. Draw structural formulas for the enethiol (the sulfur equivalent of an enol) forms of 6-mercaptopurine and 6-thioguanine. HN HN H,N H 6-Mercaptopurine 6-Thioguanine

Chemistry
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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A pioneer in designing and synthesizing antimetabolites that could destroy cancer cells was George Hitchings at the Burroughs Wellcome Company. In 1942, he initiated a pro- gram to discover DNA antimetabolites, and in 1948, he and Gertrude Elion synthesized 6-mercaptopurine, a successful drug for treating acute leukemia. Another DNA antime- tabolite synthesized by Hutchings and Elion was 6-thioguanine. Hitchings and Elion along with Sir James W. Black won the 1988 Nobel Prize in Physiology or Medicine for their discoveries of "important principles of drug treatment." In each drug, the oxygen at carbon 6 of the parent molecule is replaced by divalent sulfur. Draw structural formulas for the enethiol (the sulfur equivalent of an enol) forms of 6-mercaptopurine and 6-thioguanine. HN HN H,N H 6-Mercaptopurine 6-Thioguanine
Transcribed Image Text:A pioneer in designing and synthesizing antimetabolites that could destroy cancer cells was George Hitchings at the Burroughs Wellcome Company. In 1942, he initiated a pro- gram to discover DNA antimetabolites, and in 1948, he and Gertrude Elion synthesized 6-mercaptopurine, a successful drug for treating acute leukemia. Another DNA antime- tabolite synthesized by Hutchings and Elion was 6-thioguanine. Hitchings and Elion along with Sir James W. Black won the 1988 Nobel Prize in Physiology or Medicine for their discoveries of "important principles of drug treatment." In each drug, the oxygen at carbon 6 of the parent molecule is replaced by divalent sulfur. Draw structural formulas for the enethiol (the sulfur equivalent of an enol) forms of 6-mercaptopurine and 6-thioguanine. HN HN H,N H 6-Mercaptopurine 6-Thioguanine
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