A patient taking ketoconazole, an antifungal agent, was also prescribed dofetilide to treat arrhythmias. The therapeutic window for dofetilide is 8–15 μg/mL. The patient’s serum levels are taken 48 hours after his first dose and his serum levels are 3 μg/mL. What is the cause of these reduced serum levels?
A patient taking ketoconazole, an antifungal agent, was also prescribed dofetilide to treat arrhythmias. The therapeutic window for dofetilide is 8–15 μg/mL. The patient’s serum levels are taken 48 hours after his first dose and his serum levels are 3 μg/mL.
What is the cause of these reduced serum levels?
Dofetilide is an anti-arrhythmic medication. It works by preventing certain electrical signals in the heart from being activated, which can cause an irregular heartbeat. Treatment for an irregular heartbeat can lower your chance of blood clots, lowering your risk of heart attack or stroke. Sodium channel blockers are drugs in this class that work to treat an irregular heartbeat by blocking sodium channels, which slows impulse conduction and changes the slope of phase 0.
It can be utilised to successfully avoid the fast heartbeat generated by the circuit's reentry.
Quinidine, Amiodarone, Procainamide, Disopyramide, Tocainide, Encainide, and others are examples.
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