MK is a 58-year-old female patient (47kg) was recently admitted to a hospital due to severe COVID-related pneumonia. Her past medical history showed that she is a chronic kidney disease (CKD). Her renal function test lab result was not immediately available at the time of her admission to the hospital. She was going to be started on vancomycin 1 g IV every 12 hours for the severe pneumonia. After a loading-dose (1 g IV), two blood samples were taken from MK at 8 and 10 hours during the elimination phase (β-phase) and the plasma concentrations were found to be 14.88 and 14.21 mg/mL, respectively. Based on the concentrations given above and by referring the elimination rate constant
MK is a 58-year-old female patient (47kg) was recently admitted to a hospital due to severe
COVID-related pneumonia. Her past medical history showed that she is a chronic kidney disease
(CKD). Her renal function test lab result was not immediately available at the time of her
admission to the hospital. She was going to be started on vancomycin 1 g IV every 12 hours for
the severe pneumonia. After a loading-dose (1 g IV), two blood samples were taken from MK at 8
and 10 hours during the elimination phase (β-phase) and the plasma concentrations were found
to be 14.88 and 14.21 mg/mL, respectively. Based on the concentrations given above and by
referring the elimination rate constant table and/or the nomogram, calculate the following:
a) Adjusted dose of vancomycin, while keeping the dosing interval constant.
b) Adjusted dosing interval of vancomycin (τ), while keeping the dose constant.
A glycopeptide antibiotic called vancomycin is prescribed to treat several bacterial infections. It is advised to administer it intravenously to treat methicillin-resistant Staphylococcus aureus-caused complex skin infections, bloodstream infections, endocarditis, bone and joint infections, and meningitis. The ideal dose can be determined by measuring blood levels. As a therapy for severe Clostridium difficile colitis, vancomycin is also given orally. It is not well absorbed when given orally.
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