Answered: A mutation where Protein kinase A and…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Question

A mutation where Protein kinase A and Ca2+/calmodulin kinase 2 is inhibited

a. Increased Cytosolic Calcium

b. Decreased Cytosolic Calcium

c. No change in Cytosolic Calcium

d. Slow progressive decrease in cytosolic calcium

Expert Solution

Step 1: Effects of mutation on a protein

Mutation of a protein can lead to either of the following 3 effects;

decrease in the activity of the protein
increase in the activity of the protein or
no effect on activity of the enzyme.

Mutations generally tend to decrease the activity of the protein. Since the type of effect the mutations on PKA and Ca2+/calmodulin kinase 2 (CaMK-2) is not given, we are going to assume that the mutation leads to decrease in the activity of PKA and CaMK-2.

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