A mutation where Protein kinase A and Ca2+/calmodulin kinase 2 is inhibited   a. Increased Cytosolic Calcium b. Decreased Cytosolic Calcium c. No change in Cytosolic Calcium d. Slow progressive decrease in cytosolic calcium

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
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A mutation where Protein kinase A and Ca2+/calmodulin kinase 2 is inhibited
 
a. Increased Cytosolic Calcium
b. Decreased Cytosolic Calcium
c. No change in Cytosolic Calcium
d. Slow progressive decrease in cytosolic calcium
Expert Solution
Step 1: Effects of mutation on a protein

Mutation of a protein can lead to either of the following 3 effects;

  • decrease in the activity of the protein
  • increase in the activity of the protein or 
  • no effect on activity of the enzyme.

Mutations generally tend to decrease the activity of the protein. Since the type of effect the mutations on PKA and Ca2+/calmodulin kinase 2 (CaMK-2) is not given, we are going to assume that the mutation leads to decrease in the activity of PKA and CaMK-2.

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