A mutation in the first intron of the Minnie gene gives rise to a shorter, truncatedform of the Minnie protein that only includes amino-acids encoded by Exon 1 and 3.What kind of mutation in intron 1 could lead to this? Explain how this mutation would lead to a truncated protein. Part BA hypothetical mouse gene Minnie (Min) has the following gene structure:A5',3'BTranscription startsite5' X₁5'UTR202 105AUG312Transcription termination62UAG280site3'UTR3'5'(A) 24 3′The top diagram (A) shows the gene structure of the Minnie gene and the lowerpanel (B) shows the mature mRNA generated from that gene by transcription andsplicing, which is exported to the cytoplasm for translation.In panel A the size of the exons (black) and introns (grey) are given in basepairs.The location of the transcription start site and transcription termination site areindicated by the arrows.In panel B the 5' untranslated region (5'UTR) of the mRNA is 61 nucleotides(excluding the modified base X at the 5' end) and the 3' untranslated region(3′UTR) is 127 nucleotides: This includes a 24 nucleotide poly-A sequence addedpost-transcriptionally at the 3' end.NB: You can assume that the poly-A sequence is added to the 3′ end of the thirdexon i.e. as defined by the transcription termination site.

Name: A mutation in the first intron of the Minnie gene gives rise to a shor
Uploaded: 2024-03-20T06:42:55.000Z
Channel: Bartleby
Description: A mutation in the first intron of the Minnie gene gives rise to a shorter, truncatedform of the Minnie protein that only includes amino-acids encoded by Exon 1 and 3.What kind of mutation in intron 1 could lead to this? Explain how this mutation woul