A hydration reaction is performed using 150 mg norbornene, 0.25 mL H20, and 0.5 mL H2SO4. Then buffered with 3.5 mL 6M NaOH. Products are eco-norborneol and endo-norborneol. draw the mechanisms for this reaction and identify any major/minor/racemic products, the theoretical yield, and limiting reactant
Catalysis and Enzymatic Reactions
Catalysis is the kind of chemical reaction in which the rate (speed) of a reaction is enhanced by the catalyst which is not consumed during the process of reaction and afterward it is removed when the catalyst is not used to make up the impurity in the product. The enzymatic reaction is the reaction that is catalyzed via enzymes.
Lock And Key Model
The lock-and-key model is used to describe the catalytic enzyme activity, based on the interaction between enzyme and substrate. This model considers the lock as an enzyme and the key as a substrate to explain this model. The concept of how a unique distinct key only can have the access to open a particular lock resembles how the specific substrate can only fit into the particular active site of the enzyme. This is significant in understanding the intermolecular interaction between proteins and plays a vital role in drug interaction.
A hydration reaction is performed using 150 mg norbornene, 0.25 mL H20, and 0.5 mL H2SO4. Then buffered with 3.5 mL 6M NaOH. Products are eco-norborneol and endo-norborneol.
draw the mechanisms for this reaction and identify any major/minor/racemic products, the theoretical yield, and limiting reactant.
![Therefore, the nature of the product(s) and orientation of the addition will be deter-
mined using gas chromatography. An alternate method of analysis is to measure the
refractive index of the product.
fosc
11
2-ethyl-1-butene
18
1.
2.
+
+
H₂O
Hg(O₂CCH3)2
In Parts B and C, dilute acid treatment of the bicyclic alkene, norbornene, will be
investigated to determine which of two stereoisomeric products is formed. In this case,
the regiochemistry of addition is the same for both products, but the stereoselectivity of
addition could result in either product depending upon the mechanism of addition.
Hydration could produce either exo-norborneol or endo-norborneol or both products.
diethyl
ether
H₂SO4
MO
H₂O
-ОН
H
exo-norborneol
mp 124-126°C
NaBH4
Na
+
Prelab Assignment
1. Determine the limiting reagent in your experiment.
2. Write a flow scheme for the experiment and workup procedure.
Experimental Procedure
Do not
OH
3-methyl-3-pentanol 2
bp 123°C
In this instance, the melting behavior of the two alcohols is distinctive. Isolation of
the product and determination of the melting point permit a definitive analysis of the
product to determine if the hydroxyl group is on the "top side" of the molecule (exo-
norborneol) or the "bottom side" (endo-norborneol).
-H
OH
endo-norborneol
mp 149-151°C
Wear eye protection at all times in the laboratory.
Sulfuric acid is a corrosive oxidizer. Mercuric acetate is a highly toxic and corro-
sive solid. Sodium borede is a corrosive solid. Wear gloves to avoid skin con-
their solutions.
tact with these comp
3. Work in a hood or
stilate
+
Sa](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F52db8ee6-33d1-4aac-bbe4-ebc771de1e49%2Faf34091c-bac7-43fc-b1ae-f08771385d83%2Fy1dlk7v_processed.jpeg&w=3840&q=75)
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