Problem #2a) How many ionizable groups does the tyrosine-alanine-isoleucine-glycine tetrapeptide core ofustiloxin B have? (b) At neutral pH, what fraction of the total concentration of the tetrapeptide is expected to havethe R group of the tyrosine residue in its deprotonated, anionic form (assuming that the pK, of theR group is the same as that of the free amino acid)?c) What is the pl of the tetrapeptide (assuming that the pK,'s of the N- and C-termini are also thesame as the corresponding functional groups in a free amino acid)?

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Answered: a) How many ionizable groups does the…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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a) How many ionizable groups does the tyrosine-alanine-isoleucine-glycine tetrapeptide ustiloxin B have? ( core of