A) Discuss how proteolytic cleavage is used to achieve tight control of the activity of digestive enzymes.
A) Discuss how proteolytic cleavage is used to achieve tight control of the activity of digestive enzymes.
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
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When the expression of a single trait is influenced by two or more different non-allelic genes, it is termed as genetic interaction. According to Mendel's law of inheritance, each gene functions in its own way and does not depend on the function of another gene, i.e., a single gene controls each of seven characteristics considered, but the complex contribution of many different genes determine many traits of an organism.
Gene Expression
Gene expression is a process by which the instructions present in deoxyribonucleic acid (DNA) are converted into useful molecules such as proteins, and functional messenger ribonucleic (mRNA) molecules in the case of non-protein-coding genes.
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Transcribed Image Text:6. More enzyme activity....
A) Discuss how proteolytic cleavage is used to achieve tight control of the activity of digestive enzymes.
B) If proteolytic cleavage leads to irreversible activation of digestive enzymes, how is the activity of digestive
enzymes reduced when no longer needed? There were two ways presented this semester.
C) We looked at three serine protease enzymes: elastase, chymotrypsin, and trypsin. All three enzymes cut
peptide bonds using a similar catalytic mechanism. Explain why these are called serine proteases.
D) What are the different substrate specificities of elastase, trypsin, and chymotrypsin? And, why, from a
structural standpoint, do elastase, trypsin, and chymotrypsin have different substrate specificities?
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